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1a3c

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[[Image:1a3c.png|left|200px]]
 
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==PYRR, THE BACILLUS SUBTILIS PYRIMIDINE BIOSYNTHETIC OPERON REPRESSOR, DIMERIC FORM==
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The line below this paragraph, containing "STRUCTURE_1a3c", creates the "Structure Box" on the page.
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<StructureSection load='1a3c' size='340' side='right'caption='[[1a3c]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1a3c]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A3C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1A3C FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SM:SAMARIUM+(III)+ION'>SM</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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{{STRUCTURE_1a3c| PDB=1a3c | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1a3c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1a3c OCA], [https://pdbe.org/1a3c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1a3c RCSB], [https://www.ebi.ac.uk/pdbsum/1a3c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1a3c ProSAT]</span></td></tr>
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</table>
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===PYRR, THE BACILLUS SUBTILIS PYRIMIDINE BIOSYNTHETIC OPERON REPRESSOR, DIMERIC FORM===
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== Function ==
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[https://www.uniprot.org/uniprot/PYRR_BACSU PYRR_BACSU] Regulates transcriptional attenuation of the pyrimidine nucleotide (pyr) operon by binding in a uridine-dependent manner to specific sites on pyr mRNA. This disrupts an antiterminator hairpin in the RNA and favors formation of a downstream transcription terminator, leading to a reduced expression of downstream genes.[HAMAP-Rule:MF_01219] Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant.[HAMAP-Rule:MF_01219]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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The line below this paragraph, {{ABSTRACT_PUBMED_9551555}}, adds the Publication Abstract to the page
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Check<jmol>
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(as it appears on PubMed at http://www.pubmed.gov), where 9551555 is the PubMed ID number.
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/a3/1a3c_consurf.spt"</scriptWhenChecked>
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{{ABSTRACT_PUBMED_9551555}}
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==About this Structure==
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</jmolCheckbox>
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[[1a3c]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A3C OCA].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1a3c ConSurf].
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<div style="clear:both"></div>
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==Reference==
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__TOC__
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<ref group="xtra">PMID:009551555</ref><ref group="xtra">PMID:011917145</ref><ref group="xtra">PMID:015048824</ref><references group="xtra"/>
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</StructureSection>
[[Category: Bacillus subtilis]]
[[Category: Bacillus subtilis]]
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[[Category: Smith, J L.]]
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[[Category: Large Structures]]
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[[Category: Switzer, R W.]]
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[[Category: Smith JL]]
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[[Category: Tomchick, D R.]]
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[[Category: Switzer RW]]
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[[Category: Turner, R J.]]
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[[Category: Tomchick DR]]
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[[Category: Attenuation protein]]
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[[Category: Turner RJ]]
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[[Category: Bifunctional enzyme]]
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[[Category: Phosphoribosyltransferase]]
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[[Category: Prtase]]
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[[Category: Pyrimidine biosynthesis]]
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[[Category: Rna-binding protein]]
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[[Category: Transcription regulation]]
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[[Category: Transferase]]
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Current revision

PYRR, THE BACILLUS SUBTILIS PYRIMIDINE BIOSYNTHETIC OPERON REPRESSOR, DIMERIC FORM

PDB ID 1a3c

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