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1a58

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[[Image:1a58.gif|left|200px]]
 
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{{Structure
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==CYCLOPHILIN FROM BRUGIA MALAYI==
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|PDB= 1a58 |SIZE=350|CAPTION= <scene name='initialview01'>1a58</scene>, resolution 1.95&Aring;
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<StructureSection load='1a58' size='340' side='right'caption='[[1a58]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND=
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<table><tr><td colspan='2'>[[1a58]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Brugia_malayi Brugia malayi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A58 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1A58 FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.95&#8491;</td></tr>
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|GENE= CYCLOPHILIN ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=6279 Brugia malayi])
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1a58 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1a58 OCA], [https://pdbe.org/1a58 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1a58 RCSB], [https://www.ebi.ac.uk/pdbsum/1a58 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1a58 ProSAT]</span></td></tr>
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}}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CYP1_BRUMA CYP1_BRUMA] PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/a5/1a58_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1a58 ConSurf].
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<div style="clear:both"></div>
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'''CYCLOPHILIN FROM BRUGIA MALAYI'''
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==See Also==
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*[[Cyclophilin 3D structures|Cyclophilin 3D structures]]
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__TOC__
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==Overview==
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</StructureSection>
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A structure of residues 1-177 of the cyclophilin domain of a large divergent cyclophilin from the filarial nematode parasite Brugia malayi has been crystallised and solved in two different crystal forms. The active site has a similar structure to that of human cyclophilin A. Two of the 13 residues important in forming the human cyclophilin A/cyclosporin A complex are altered in the B. malayi cyclophilin and explain the relatively poor inhibition of peptidyl prolyl isomerase activity by cyclosporin A.
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==About this Structure==
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1A58 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Brugia_malayi Brugia malayi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A58 OCA].
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==Reference==
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The X-ray structure of a divergent cyclophilin from the nematode parasite Brugia malayi., Taylor P, Page AP, Kontopidis G, Husi H, Walkinshaw MD, FEBS Lett. 1998 Mar 27;425(2):361-6. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9559680 9559680]
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[[Category: Brugia malayi]]
[[Category: Brugia malayi]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Husi, H.]]
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[[Category: Husi H]]
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[[Category: Kontopidis, G.]]
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[[Category: Kontopidis G]]
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[[Category: Page, A P.]]
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[[Category: Page AP]]
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[[Category: Taylor, P.]]
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[[Category: Taylor P]]
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[[Category: Walkinshaw, M D.]]
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[[Category: Walkinshaw MD]]
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[[Category: isomerase]]
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[[Category: ppiase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 09:53:04 2008''
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Current revision

CYCLOPHILIN FROM BRUGIA MALAYI

PDB ID 1a58

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