1a68

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(New page: 200px<br /><applet load="1a68" size="450" color="white" frame="true" align="right" spinBox="true" caption="1a68, resolution 1.8&Aring;" /> '''CRYSTAL STRUCTURE OF ...)
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[[Image:1a68.jpg|left|200px]]<br /><applet load="1a68" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1a68, resolution 1.8&Aring;" />
 
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'''CRYSTAL STRUCTURE OF THE TETRAMERIZATION DOMAIN OF THE SHAKER POTASSIUM CHANNEL'''<br />
 
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==Overview==
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==CRYSTAL STRUCTURE OF THE TETRAMERIZATION DOMAIN OF THE SHAKER POTASSIUM CHANNEL==
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Voltage-dependent, ion-selective channels such as Na+, Ca2+ and K+ channel, proteins function as tetrameric assemblies of identical or similar, subunits. The clustering of four subunits is thought to create an aqueous, pore centred at the four-fold symmetry axis. The highly conserved, amino-terminal cytoplasmic domain (approximately 130 amino acids), immediately preceding the first putative transmembrane helix S1 is, designated T1. It is known to confer specificity for tetramer formation, so the heteromeric assembly of K+-channel subunits is an important, mechanism for the observed channel diversity. We have determined the, crystal structure of the T1 domain of a Shaker potassium channel at 1.55 A, resolution. The structure reveals that four identical subunits are, arranged in a four-fold symmetry surrounding a centrally located pore, about 20 A in length. Subfamily-specific assembly is provided primarily by, polar interactions encoded in a conserved set of amino acids at its, tetramerization interface. Most highly conserved amino acids in the T1, domain of all known potassium channels are found in the core of the, protein, indicating a common structural framework for the tetramer, assembly.
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<StructureSection load='1a68' size='340' side='right'caption='[[1a68]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1a68]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Aplysia_californica Aplysia californica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A68 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1A68 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1a68 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1a68 OCA], [https://pdbe.org/1a68 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1a68 RCSB], [https://www.ebi.ac.uk/pdbsum/1a68 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1a68 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q16968_APLCA Q16968_APLCA]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/a6/1a68_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1a68 ConSurf].
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<div style="clear:both"></div>
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==About this Structure==
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==See Also==
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1A68 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Aplysia_californica Aplysia californica]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1A68 OCA].
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*[[Potassium channel 3D structures|Potassium channel 3D structures]]
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__TOC__
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==Reference==
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</StructureSection>
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Crystal structure of the tetramerization domain of the Shaker potassium channel., Kreusch A, Pfaffinger PJ, Stevens CF, Choe S, Nature. 1998 Apr 30;392(6679):945-8. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9582078 9582078]
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[[Category: Aplysia californica]]
[[Category: Aplysia californica]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Choe, S.]]
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[[Category: Choe S]]
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[[Category: Kreusch, A.]]
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[[Category: Kreusch A]]
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[[Category: Pfaffinger, P.J.]]
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[[Category: Pfaffinger PJ]]
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[[Category: Stevens, C.F.]]
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[[Category: Stevens CF]]
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[[Category: aplysia kv1.1]]
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[[Category: potassium channels]]
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[[Category: tetramerization domain]]
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[[Category: x-ray structure]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Sat Nov 24 22:27:32 2007''
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Current revision

CRYSTAL STRUCTURE OF THE TETRAMERIZATION DOMAIN OF THE SHAKER POTASSIUM CHANNEL

PDB ID 1a68

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