1a8s

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[[Image:1a8s.gif|left|200px]]
 
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{{Structure
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==CHLOROPEROXIDASE F/PROPIONATE COMPLEX==
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|PDB= 1a8s |SIZE=350|CAPTION= <scene name='initialview01'>1a8s</scene>, resolution 1.80&Aring;
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<StructureSection load='1a8s' size='340' side='right'caption='[[1a8s]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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|SITE= <scene name='pdbsite=NUL:Catalytic+Triad'>NUL</scene>
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene> and <scene name='pdbligand=PPI:PROPANOIC ACID'>PPI</scene>
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<table><tr><td colspan='2'>[[1a8s]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_fluorescens Pseudomonas fluorescens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A8S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1A8S FirstGlance]. <br>
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|ACTIVITY= [http://en.wikipedia.org/wiki/Chloride_peroxidase Chloride peroxidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.11.1.10 1.11.1.10]
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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|GENE= CPOF ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=294 Pseudomonas fluorescens])
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PPI:PROPANOIC+ACID'>PPI</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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}}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1a8s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1a8s OCA], [https://pdbe.org/1a8s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1a8s RCSB], [https://www.ebi.ac.uk/pdbsum/1a8s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1a8s ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PRXC_PSEFL PRXC_PSEFL]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/a8/1a8s_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1a8s ConSurf].
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<div style="clear:both"></div>
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'''CHLOROPEROXIDASE F/PROPIONATE COMPLEX'''
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==See Also==
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*[[Haloperoxidase|Haloperoxidase]]
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__TOC__
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==Overview==
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</StructureSection>
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The structures of cofactor-free haloperoxidases from Streptomyces aureofaciens, Streptomyces lividans, and Pseudomonas fluorescens have been determined at resolutions between 1.9 A and 1.5 A. The structures of two enzymes complexed with benzoate or propionate identify the binding site for the organic acids which are required for the haloperoxidase activity. Based on these complexes and on the structure of an inactive variant, a reaction mechanism is proposed for the halogenation reaction with peroxoacid and hypohalous acid as reaction intermediates. Comparison of the structures suggests that a specific halide binding site is absent in the enzymes but that hydrophobic organic compounds may fit into the active site pocket for halogenation at preferential sites.
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[[Category: Large Structures]]
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==About this Structure==
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1A8S is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Pseudomonas_fluorescens Pseudomonas fluorescens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A8S OCA].
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==Reference==
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Structural investigation of the cofactor-free chloroperoxidases., Hofmann B, Tolzer S, Pelletier I, Altenbuchner J, van Pee KH, Hecht HJ, J Mol Biol. 1998 Jun 19;279(4):889-900. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9642069 9642069]
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[[Category: Chloride peroxidase]]
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[[Category: Pseudomonas fluorescens]]
[[Category: Pseudomonas fluorescens]]
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[[Category: Single protein]]
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[[Category: Altenbuchner J]]
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[[Category: Altenbuchner, J.]]
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[[Category: Hecht H-J]]
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[[Category: Hecht, H J.]]
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[[Category: Hofmann B]]
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[[Category: Hofmann, B.]]
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[[Category: Pelletier I]]
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[[Category: Pee, K H.Van.]]
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[[Category: Toelzer S]]
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[[Category: Pelletier, I.]]
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[[Category: Van Pee K-H]]
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[[Category: Toelzer, S.]]
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[[Category: PPI]]
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[[Category: SO4]]
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[[Category: haloperoxidase]]
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[[Category: oxidoreductase]]
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[[Category: propionate complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 09:54:31 2008''
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Current revision

CHLOROPEROXIDASE F/PROPIONATE COMPLEX

PDB ID 1a8s

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