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1ahq

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(New page: 200px<br /><applet load="1ahq" size="450" color="white" frame="true" align="right" spinBox="true" caption="1ahq, resolution 2.3&Aring;" /> '''RECOMBINANT ACTOPHORI...)
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[[Image:1ahq.gif|left|200px]]<br /><applet load="1ahq" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1ahq, resolution 2.3&Aring;" />
 
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'''RECOMBINANT ACTOPHORIN'''<br />
 
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==Overview==
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==RECOMBINANT ACTOPHORIN==
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Actophorin is a member of the actin-depolymerizing factor/cofilin family., It severs actin filaments and sequesters actin monomers. The crystal, structure of actophorin will help to elucidate actin-ADF/cofilin, interactions.
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<StructureSection load='1ahq' size='340' side='right'caption='[[1ahq]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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== Structural highlights ==
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==About this Structure==
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<table><tr><td colspan='2'>[[1ahq]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Acanthamoeba_castellanii Acanthamoeba castellanii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AHQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1AHQ FirstGlance]. <br>
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1AHQ is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Acanthamoeba_castellanii Acanthamoeba castellanii]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1AHQ OCA].
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ahq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ahq OCA], [https://pdbe.org/1ahq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ahq RCSB], [https://www.ebi.ac.uk/pdbsum/1ahq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ahq ProSAT]</span></td></tr>
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==Reference==
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</table>
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Crystal structure of the actin-binding protein actophorin from Acanthamoeba., Leonard SA, Gittis AG, Petrella EC, Pollard TD, Lattman EE, Nat Struct Biol. 1997 May;4(5):369-73. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9145107 9145107]
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== Function ==
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[https://www.uniprot.org/uniprot/ACTP_ACACA ACTP_ACACA] Forms a one to one complex with monomeric actin. Can regulate the pool available for polymerization. Severs actin filaments in a dose-dependent manner.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ah/1ahq_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ahq ConSurf].
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<div style="clear:both"></div>
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__TOC__
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</StructureSection>
[[Category: Acanthamoeba castellanii]]
[[Category: Acanthamoeba castellanii]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Gittis, A.G.]]
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[[Category: Gittis AG]]
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[[Category: Lattman, E.E.]]
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[[Category: Lattman EE]]
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[[Category: Leonard, S.A.]]
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[[Category: Leonard SA]]
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[[Category: Petrella, E.C.]]
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[[Category: Petrella EC]]
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[[Category: Pollard, T.D.]]
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[[Category: Pollard TD]]
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[[Category: actin binding protein]]
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[[Category: actophorin]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Nov 20 10:51:59 2007''
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Current revision

RECOMBINANT ACTOPHORIN

PDB ID 1ahq

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