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1aih

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[[Image:1aih.gif|left|200px]]
 
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==CATALYTIC DOMAIN OF BACTERIOPHAGE HP1 INTEGRASE==
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The line below this paragraph, containing "STRUCTURE_1aih", creates the "Structure Box" on the page.
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<StructureSection load='1aih' size='340' side='right'caption='[[1aih]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1aih]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Haemophilus_virus_HP1 Haemophilus virus HP1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AIH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1AIH FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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{{STRUCTURE_1aih| PDB=1aih | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1aih FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1aih OCA], [https://pdbe.org/1aih PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1aih RCSB], [https://www.ebi.ac.uk/pdbsum/1aih PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1aih ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/VINT_BPHC1 VINT_BPHC1] Integrase is necessary for integration of the phage into the host genome by site-specific recombination. In conjunction with excisionase, integrase is also necessary for excision of the prophage from the host genome.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ai/1aih_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1aih ConSurf].
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<div style="clear:both"></div>
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'''CATALYTIC DOMAIN OF BACTERIOPHAGE HP1 INTEGRASE'''
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==See Also==
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*[[Retroviral integrase 3D structures|Retroviral integrase 3D structures]]
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__TOC__
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==Overview==
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</StructureSection>
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HP1 integrase promotes site-specific recombination of the HP1 genome into that of Haemophilus influenzae. The isolated C-terminal domain (residues 165-337) of the protein interacts with the recombination site and contains the four catalytic residues conserved in the integrase family. This domain represents a novel fold consisting principally of well-packed alpha helices, a surface beta sheet, and an ordered 17-residue C-terminal tail. The conserved triad of basic residues and the active-site tyrosine are contributed by a single monomer and occupy fixed positions in a defined active-site cleft. Dimers are formed by mutual interactions of the tail of one monomer with an adjacent monomer; this orients active-site clefts antiparallel to each other.
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[[Category: Haemophilus virus HP1]]
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[[Category: Large Structures]]
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==About this Structure==
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[[Category: Dyda F]]
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1AIH is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Haemophilus_phage_hp1 Haemophilus phage hp1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AIH OCA].
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[[Category: Hickman AB]]
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[[Category: Scocca JJ]]
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==Reference==
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[[Category: Waninger S]]
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Molecular organization in site-specific recombination: the catalytic domain of bacteriophage HP1 integrase at 2.7 A resolution., Hickman AB, Waninger S, Scocca JJ, Dyda F, Cell. 1997 Apr 18;89(2):227-37. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9108478 9108478]
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[[Category: Haemophilus phage hp1]]
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[[Category: Single protein]]
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[[Category: Dyda, F.]]
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[[Category: Hickman, A B.]]
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[[Category: Scocca, J J.]]
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[[Category: Waninger, S.]]
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[[Category: Dna integration]]
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[[Category: Recombination]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 10:18:41 2008''
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Current revision

CATALYTIC DOMAIN OF BACTERIOPHAGE HP1 INTEGRASE

PDB ID 1aih

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