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1aj0

From Proteopedia

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{{Seed}}
 
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[[Image:1aj0.png|left|200px]]
 
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==CRYSTAL STRUCTURE OF A TERNARY COMPLEX OF E. COLI DIHYDROPTEROATE SYNTHASE==
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The line below this paragraph, containing "STRUCTURE_1aj0", creates the "Structure Box" on the page.
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<StructureSection load='1aj0' size='340' side='right'caption='[[1aj0]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1aj0]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AJ0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1AJ0 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PH2:2-AMINO-6-HYDROXYMETHYL-7,8-DIHYDRO-3H-PTERIDIN-4-ONE'>PH2</scene>, <scene name='pdbligand=SAN:SULFANILAMIDE'>SAN</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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{{STRUCTURE_1aj0| PDB=1aj0 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1aj0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1aj0 OCA], [https://pdbe.org/1aj0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1aj0 RCSB], [https://www.ebi.ac.uk/pdbsum/1aj0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1aj0 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/DHPS_ECOLI DHPS_ECOLI] DHPS catalyzes the formation of the immediate precursor of folic acid. It is implicated in resistance to sulfonamide.<ref>PMID:368012</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/aj/1aj0_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1aj0 ConSurf].
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<div style="clear:both"></div>
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===CRYSTAL STRUCTURE OF A TERNARY COMPLEX OF E. COLI DIHYDROPTEROATE SYNTHASE===
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==See Also==
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*[[Dihydropteroate synthase 3D structures|Dihydropteroate synthase 3D structures]]
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== References ==
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<references/>
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The line below this paragraph, {{ABSTRACT_PUBMED_9187658}}, adds the Publication Abstract to the page
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 9187658 is the PubMed ID number.
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</StructureSection>
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{{ABSTRACT_PUBMED_9187658}}
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==About this Structure==
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1AJ0 is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AJ0 OCA].
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==Reference==
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<ref group="xtra">PMID:9187658</ref><references group="xtra"/>
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[[Category: Dihydropteroate synthase]]
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[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
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[[Category: Achari, A.]]
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[[Category: Large Structures]]
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[[Category: Bryant, P K.]]
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[[Category: Achari A]]
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[[Category: Champness, J N.]]
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[[Category: Bryant PK]]
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[[Category: Rosemond, J.]]
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[[Category: Champness JN]]
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[[Category: Somers, D O.]]
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[[Category: Rosemond J]]
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[[Category: Stammers, D K.]]
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[[Category: Somers DO]]
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[[Category: Antibiotic]]
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[[Category: Stammers DK]]
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[[Category: Biosynthesis]]
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[[Category: Folate]]
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[[Category: Resistance]]
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[[Category: Synthase]]
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[[Category: Transferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 10:59:42 2009''
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Current revision

CRYSTAL STRUCTURE OF A TERNARY COMPLEX OF E. COLI DIHYDROPTEROATE SYNTHASE

PDB ID 1aj0

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