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1ajz

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{{Seed}}
 
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[[Image:1ajz.png|left|200px]]
 
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==STRUCTURE OF DIHYDROPTEROATE PYROPHOSPHORYLASE==
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The line below this paragraph, containing "STRUCTURE_1ajz", creates the "Structure Box" on the page.
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<StructureSection load='1ajz' size='340' side='right'caption='[[1ajz]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1ajz]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AJZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1AJZ FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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{{STRUCTURE_1ajz| PDB=1ajz | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ajz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ajz OCA], [https://pdbe.org/1ajz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ajz RCSB], [https://www.ebi.ac.uk/pdbsum/1ajz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ajz ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/DHPS_ECOLI DHPS_ECOLI] DHPS catalyzes the formation of the immediate precursor of folic acid. It is implicated in resistance to sulfonamide.<ref>PMID:368012</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/aj/1ajz_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ajz ConSurf].
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<div style="clear:both"></div>
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===STRUCTURE OF DIHYDROPTEROATE PYROPHOSPHORYLASE===
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==See Also==
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*[[Dihydropteroate synthase 3D structures|Dihydropteroate synthase 3D structures]]
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== References ==
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<!--
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<references/>
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The line below this paragraph, {{ABSTRACT_PUBMED_9187658}}, adds the Publication Abstract to the page
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 9187658 is the PubMed ID number.
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</StructureSection>
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{{ABSTRACT_PUBMED_9187658}}
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==About this Structure==
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1AJZ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AJZ OCA].
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==Reference==
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Crystal structure of the anti-bacterial sulfonamide drug target dihydropteroate synthase., Achari A, Somers DO, Champness JN, Bryant PK, Rosemond J, Stammers DK, Nat Struct Biol. 1997 Jun;4(6):490-7. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9187658 9187658]
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[[Category: Dihydropteroate synthase]]
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[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Achari, A.]]
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[[Category: Achari A]]
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[[Category: Bryant, P K.]]
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[[Category: Bryant PK]]
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[[Category: Champness, J N.]]
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[[Category: Champness JN]]
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[[Category: Rosemond, J.]]
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[[Category: Rosemond J]]
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[[Category: Somers, D O.]]
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[[Category: Somers DO]]
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[[Category: Stammers, D K.]]
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[[Category: Stammers DK]]
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[[Category: Antibiotic]]
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[[Category: Biosynthesis]]
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[[Category: Folate]]
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[[Category: Resistance]]
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[[Category: Synthase]]
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[[Category: Transferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 17:00:33 2008''
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Current revision

STRUCTURE OF DIHYDROPTEROATE PYROPHOSPHORYLASE

PDB ID 1ajz

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