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1ama

From Proteopedia

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{{Seed}}
 
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[[Image:1ama.png|left|200px]]
 
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==DOMAIN CLOSURE IN MITOCHONDRIAL ASPARTATE AMINOTRANSFERASE==
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The line below this paragraph, containing "STRUCTURE_1ama", creates the "Structure Box" on the page.
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<StructureSection load='1ama' size='340' side='right'caption='[[1ama]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1ama]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AMA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1AMA FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PLA:2-[(3-HYDROXY-2-METHYL-5-PHOSPHONOOXYMETHYL-PYRIDIN-4-YLMETHYL)-AMINO]-2-METHYL-SUCCINIC+ACID'>PLA</scene></td></tr>
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{{STRUCTURE_1ama| PDB=1ama | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ama FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ama OCA], [https://pdbe.org/1ama PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ama RCSB], [https://www.ebi.ac.uk/pdbsum/1ama PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ama ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/AATM_CHICK AATM_CHICK] Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA). Plays a key role in amino acid metabolism. Important for metabolite exchange between mitochondria and cytosol. May facilitate cellular uptake of long-chain free fatty acids (By similarity).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/am/1ama_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ama ConSurf].
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<div style="clear:both"></div>
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===DOMAIN CLOSURE IN MITOCHONDRIAL ASPARTATE AMINOTRANSFERASE===
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==See Also==
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*[[Aspartate aminotransferase 3D structures|Aspartate aminotransferase 3D structures]]
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__TOC__
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</StructureSection>
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The line below this paragraph, {{ABSTRACT_PUBMED_1522585}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 1522585 is the PubMed ID number.
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{{ABSTRACT_PUBMED_1522585}}
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==About this Structure==
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1AMA is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AMA OCA].
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==Reference==
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Domain closure in mitochondrial aspartate aminotransferase., McPhalen CA, Vincent MG, Picot D, Jansonius JN, Lesk AM, Chothia C, J Mol Biol. 1992 Sep 5;227(1):197-213. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/1522585 1522585]
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[[Category: Aspartate transaminase]]
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[[Category: Gallus gallus]]
[[Category: Gallus gallus]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Genovesio-Taverne, J C.]]
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[[Category: Genovesio-Taverne J-C]]
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[[Category: Jansonius, J N.]]
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[[Category: Jansonius JN]]
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[[Category: Vincent, M G.]]
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[[Category: Vincent MG]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 17:08:30 2008''
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Current revision

DOMAIN CLOSURE IN MITOCHONDRIAL ASPARTATE AMINOTRANSFERASE

PDB ID 1ama

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