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1amx

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[[Image:1amx.jpg|left|200px]]
 
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{{Structure
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==COLLAGEN-BINDING DOMAIN FROM A STAPHYLOCOCCUS AUREUS ADHESIN==
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|PDB= 1amx |SIZE=350|CAPTION= <scene name='initialview01'>1amx</scene>, resolution 2.0&Aring;
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<StructureSection load='1amx' size='340' side='right'caption='[[1amx]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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|SITE= <scene name='pdbsite=CBR:Collagen-Binding+Residues+Identified+By+Site-Directed+Mu+...'>CBR</scene>
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== Structural highlights ==
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|LIGAND=
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<table><tr><td colspan='2'>[[1amx]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AMX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1AMX FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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|GENE= CNA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1280 Staphylococcus aureus])
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1amx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1amx OCA], [https://pdbe.org/1amx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1amx RCSB], [https://www.ebi.ac.uk/pdbsum/1amx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1amx ProSAT]</span></td></tr>
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|DOMAIN=
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</table>
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|RELATEDENTRY=
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== Function ==
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1amx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1amx OCA], [http://www.ebi.ac.uk/pdbsum/1amx PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1amx RCSB]</span>
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[https://www.uniprot.org/uniprot/CNA_STAAU CNA_STAAU] Mediates attachment of staphylococcal cells to collagen-containing substrata.
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}}
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/am/1amx_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1amx ConSurf].
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<div style="clear:both"></div>
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'''COLLAGEN-BINDING DOMAIN FROM A STAPHYLOCOCCUS AUREUS ADHESIN'''
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==See Also==
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*[[Adhesin 3D structures|Adhesin 3D structures]]
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__TOC__
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==Overview==
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</StructureSection>
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The crystal structure of the recombinant 19,000 M(r) binding domain from the Staphylococcus aureus collagen adhesin has been determined at 2 A resolution. The domain fold is a jelly-roll, composed of two antiparallel beta-sheets and two short alpha-helices. Triple-helical collagen model probes were used in a systematic docking search to identify the collagen-binding site. A groove on beta-sheet I exhibited the best surface complementarity to the collagen probes. This site partially overlaps with the peptide sequence previously shown to be critical for collagen binding. Recombinant proteins containing single amino acid mutations designed to disrupt the surface of the putative binding site exhibited significantly lower affinities for collagen. Here we present a structural perspective for the mode of collagen binding by a bacterial surface protein.
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[[Category: Large Structures]]
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==About this Structure==
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1AMX is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AMX OCA].
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==Reference==
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Structure of the collagen-binding domain from a Staphylococcus aureus adhesin., Symersky J, Patti JM, Carson M, House-Pompeo K, Teale M, Moore D, Jin L, Schneider A, DeLucas LJ, Hook M, Narayana SV, Nat Struct Biol. 1997 Oct;4(10):833-8. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9334749 9334749]
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[[Category: Single protein]]
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[[Category: Staphylococcus aureus]]
[[Category: Staphylococcus aureus]]
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[[Category: Narayana, S.]]
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[[Category: Narayana S]]
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[[Category: Symersky, J.]]
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[[Category: Symersky J]]
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[[Category: bacterial adhesin]]
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[[Category: mscramm]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 18:43:34 2008''
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Current revision

COLLAGEN-BINDING DOMAIN FROM A STAPHYLOCOCCUS AUREUS ADHESIN

PDB ID 1amx

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