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1aqv

From Proteopedia

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{{Seed}}
 
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[[Image:1aqv.png|left|200px]]
 
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<!--
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==GLUTATHIONE S-TRANSFERASE IN COMPLEX WITH P-BROMOBENZYLGLUTATHIONE==
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The line below this paragraph, containing "STRUCTURE_1aqv", creates the "Structure Box" on the page.
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<StructureSection load='1aqv' size='340' side='right'caption='[[1aqv]], [[Resolution|resolution]] 1.94&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1aqv]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AQV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1AQV FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.94&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0HG:N-[(4S)-4-AMMONIO-4-CARBOXYBUTANOYL]-S-(4-BROMOBENZYL)-L-CYSTEINYLGLYCINE'>0HG</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene></td></tr>
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{{STRUCTURE_1aqv| PDB=1aqv | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1aqv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1aqv OCA], [https://pdbe.org/1aqv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1aqv RCSB], [https://www.ebi.ac.uk/pdbsum/1aqv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1aqv ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/GSTP1_HUMAN GSTP1_HUMAN] Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Regulates negatively CDK5 activity via p25/p35 translocation to prevent neurodegeneration.<ref>PMID:21668448</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/aq/1aqv_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1aqv ConSurf].
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<div style="clear:both"></div>
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===GLUTATHIONE S-TRANSFERASE IN COMPLEX WITH P-BROMOBENZYLGLUTATHIONE===
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==See Also==
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*[[Glutathione S-transferase 3D structures|Glutathione S-transferase 3D structures]]
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== References ==
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<references/>
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The line below this paragraph, {{ABSTRACT_PUBMED_9351803}}, adds the Publication Abstract to the page
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 9351803 is the PubMed ID number.
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</StructureSection>
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-->
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{{ABSTRACT_PUBMED_9351803}}
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==About this Structure==
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1AQV is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AQV OCA].
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==Reference==
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Structures of class pi glutathione S-transferase from human placenta in complex with substrate, transition-state analogue and inhibitor., Prade L, Huber R, Manoharan TH, Fahl WE, Reuter W, Structure. 1997 Oct 15;5(10):1287-95. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9351803 9351803]
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[[Category: Glutathione transferase]]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Fahl, W E.]]
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[[Category: Fahl WE]]
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[[Category: Huber, R.]]
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[[Category: Huber R]]
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[[Category: Manoharan, T H.]]
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[[Category: Manoharan TH]]
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[[Category: Prade, L.]]
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[[Category: Prade L]]
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[[Category: Reuter, W.]]
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[[Category: Reuter W]]
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[[Category: Class pi]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep 3 10:39:35 2008''
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Current revision

GLUTATHIONE S-TRANSFERASE IN COMPLEX WITH P-BROMOBENZYLGLUTATHIONE

PDB ID 1aqv

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