This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1bai

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (06:34, 7 February 2024) (edit) (undo)
 
(11 intermediate revisions not shown.)
Line 1: Line 1:
-
{{Seed}}
 
-
[[Image:1bai.png|left|200px]]
 
-
<!--
+
==Crystal structure of Rous sarcoma virus protease in complex with inhibitor==
-
The line below this paragraph, containing "STRUCTURE_1bai", creates the "Structure Box" on the page.
+
<StructureSection load='1bai' size='340' side='right'caption='[[1bai]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[1bai]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rous_sarcoma_virus Rous sarcoma virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BAI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1BAI FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
-
-->
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0Q4:N-[(2R)-2-({N~5~-[AMINO(IMINIO)METHYL]-L-ORNITHYL-L-VALYL}AMINO)-4-METHYLPENTYL]-L-PHENYLALANYL-L-ALPHA-GLUTAMYL-L-ALANYL-L-NORLEUCINAMIDE'>0Q4</scene></td></tr>
-
{{STRUCTURE_1bai| PDB=1bai | SCENE= }}
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1bai FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bai OCA], [https://pdbe.org/1bai PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1bai RCSB], [https://www.ebi.ac.uk/pdbsum/1bai PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1bai ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/GAG_RSVP GAG_RSVP] Capsid protein p27 forms the spherical core of the virus that encapsulates the genomic RNA-nucleocapsid complex (By similarity). The aspartyl protease mediates proteolytic cleavages of Gag and Gag-Pol polyproteins during or shortly after the release of the virion from the plasma membrane. Cleavages take place as an ordered, step-wise cascade to yield mature proteins. This process is called maturation. Displays maximal activity during the budding process just prior to particle release from the cell (By similarity).
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ba/1bai_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1bai ConSurf].
 +
<div style="clear:both"></div>
-
===STRUCTURAL BASIS FOR SPECIFICITY OF RETROVIRAL PROTEASES===
+
==See Also==
-
 
+
*[[Virus protease 3D structures|Virus protease 3D structures]]
-
 
+
__TOC__
-
<!--
+
</StructureSection>
-
The line below this paragraph, {{ABSTRACT_PUBMED_9521772}}, adds the Publication Abstract to the page
+
[[Category: Large Structures]]
-
(as it appears on PubMed at http://www.pubmed.gov), where 9521772 is the PubMed ID number.
+
-
-->
+
-
{{ABSTRACT_PUBMED_9521772}}
+
-
 
+
-
==About this Structure==
+
-
1BAI is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Rous_sarcoma_virus Rous sarcoma virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BAI OCA].
+
-
 
+
-
==Reference==
+
-
Structural basis for specificity of retroviral proteases., Wu J, Adomat JM, Ridky TW, Louis JM, Leis J, Harrison RW, Weber IT, Biochemistry. 1998 Mar 31;37(13):4518-26. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9521772 9521772]
+
[[Category: Rous sarcoma virus]]
[[Category: Rous sarcoma virus]]
-
[[Category: Single protein]]
+
[[Category: Adomat JM]]
-
[[Category: Adomat, J M.]]
+
[[Category: Harrison RW]]
-
[[Category: Harrison, R W.]]
+
[[Category: Leis J]]
-
[[Category: Leis, J.]]
+
[[Category: Louis JM]]
-
[[Category: Louis, J M.]]
+
[[Category: Ridky TW]]
-
[[Category: Ridky, T W.]]
+
[[Category: Weber IT]]
-
[[Category: Weber, I T.]]
+
[[Category: Wu J]]
-
[[Category: Wu, J.]]
+
-
[[Category: Crystal structure]]
+
-
[[Category: Human immunodeficiency virus protease]]
+
-
[[Category: Protein-mediated interaction]]
+
-
[[Category: Rous sarcoma virus protease]]
+
-
[[Category: Viral maturation]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 18:42:15 2008''
+

Current revision

Crystal structure of Rous sarcoma virus protease in complex with inhibitor

PDB ID 1bai

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1bai"
Personal tools