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1bd8

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{{Seed}}
 
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[[Image:1bd8.png|left|200px]]
 
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==STRUCTURE OF CDK INHIBITOR P19INK4D==
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The line below this paragraph, containing "STRUCTURE_1bd8", creates the "Structure Box" on the page.
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<StructureSection load='1bd8' size='340' side='right'caption='[[1bd8]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1bd8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BD8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1BD8 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1bd8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bd8 OCA], [https://pdbe.org/1bd8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1bd8 RCSB], [https://www.ebi.ac.uk/pdbsum/1bd8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1bd8 ProSAT]</span></td></tr>
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{{STRUCTURE_1bd8| PDB=1bd8 | SCENE= }}
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</table>
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== Function ==
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===STRUCTURE OF CDK INHIBITOR P19INK4D===
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[https://www.uniprot.org/uniprot/CDN2D_HUMAN CDN2D_HUMAN] Interacts strongly with CDK4 and CDK6 and inhibits them.<ref>PMID:7739548</ref> <ref>PMID:8741839</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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The line below this paragraph, {{ABSTRACT_PUBMED_9782052}}, adds the Publication Abstract to the page
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<jmolCheckbox>
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(as it appears on PubMed at http://www.pubmed.gov), where 9782052 is the PubMed ID number.
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bd/1bd8_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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{{ABSTRACT_PUBMED_9782052}}
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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==About this Structure==
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1bd8 ConSurf].
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1BD8 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BD8 OCA].
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<div style="clear:both"></div>
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== References ==
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==Reference==
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<references/>
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Structure of human cyclin-dependent kinase inhibitor p19INK4d: comparison to known ankyrin-repeat-containing structures and implications for the dysfunction of tumor suppressor p16INK4a., Baumgartner R, Fernandez-Catalan C, Winoto A, Huber R, Engh RA, Holak TA, Structure. 1998 Oct 15;6(10):1279-90. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9782052 9782052]
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Baumgartner, R.]]
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[[Category: Baumgartner R]]
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[[Category: Engh, R.]]
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[[Category: Engh R]]
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[[Category: Fernandez-Catalan, C.]]
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[[Category: Fernandez-Catalan C]]
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[[Category: Holak, T A.]]
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[[Category: Holak TA]]
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[[Category: Huber, R.]]
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[[Category: Huber R]]
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[[Category: Winoto, A.]]
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[[Category: Winoto A]]
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[[Category: Ankyrin motif]]
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[[Category: Cdk4/6 inhibitor]]
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[[Category: Tumor suppressor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 18:52:51 2008''
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Current revision

STRUCTURE OF CDK INHIBITOR P19INK4D

PDB ID 1bd8

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