1bg3

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(New page: 200px<br /><applet load="1bg3" size="450" color="white" frame="true" align="right" spinBox="true" caption="1bg3, resolution 2.8&Aring;" /> '''RAT BRAIN HEXOKINASE ...)
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[[Image:1bg3.gif|left|200px]]<br /><applet load="1bg3" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1bg3, resolution 2.8&Aring;" />
 
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'''RAT BRAIN HEXOKINASE TYPE I COMPLEX WITH GLUCOSE AND INHIBITOR GLUCOSE-6-PHOSPHATE'''<br />
 
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==Overview==
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==RAT BRAIN HEXOKINASE TYPE I COMPLEX WITH GLUCOSE AND INHIBITOR GLUCOSE-6-PHOSPHATE==
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We have determined the structures of the glucose-6-phosphate, (G6P)-inhibitable 100,000 Mr Type I hexokinase from rat and the, G6P-sensitive 50,000 Mr hexokinase from Schistosoma mansoni at a, resolution of 2.8 and 2.6 A respectively. The structures define the, glucose and G6P binding sites in these enzymes, suggest the mechanisms of, intradomain G6P inhibition and activity loss in the Type I hexokinase, N-terminal half, and reveal the structure of the membrane targeting motif, that integrates the Type I hexokinase into the outer mitochondrial, membrane.
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<StructureSection load='1bg3' size='340' side='right'caption='[[1bg3]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1bg3]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BG3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1BG3 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=G6P:ALPHA-D-GLUCOSE-6-PHOSPHATE'>G6P</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1bg3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bg3 OCA], [https://pdbe.org/1bg3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1bg3 RCSB], [https://www.ebi.ac.uk/pdbsum/1bg3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1bg3 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/HXK1_RAT HXK1_RAT]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bg/1bg3_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1bg3 ConSurf].
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<div style="clear:both"></div>
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==About this Structure==
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==See Also==
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1BG3 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus] with GLC, G6P and CA as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Hexokinase Hexokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.1 2.7.1.1] Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1BG3 OCA].
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*[[Hexokinase 3D structures|Hexokinase 3D structures]]
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__TOC__
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==Reference==
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</StructureSection>
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The structure of mammalian hexokinase-1., Mulichak AM, Wilson JE, Padmanabhan K, Garavito RM, Nat Struct Biol. 1998 Jul;5(7):555-60. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9665168 9665168]
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[[Category: Large Structures]]
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[[Category: Hexokinase]]
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[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
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[[Category: Single protein]]
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[[Category: Garavito RM]]
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[[Category: Garavito, R.M.]]
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[[Category: Mulichak AM]]
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[[Category: Mulichak, A.M.]]
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[[Category: CA]]
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[[Category: G6P]]
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[[Category: GLC]]
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[[Category: hexokinase]]
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[[Category: phosphotransferase]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Nov 20 11:37:21 2007''
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Current revision

RAT BRAIN HEXOKINASE TYPE I COMPLEX WITH GLUCOSE AND INHIBITOR GLUCOSE-6-PHOSPHATE

PDB ID 1bg3

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