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1bgw

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[[Image:1bgw.gif|left|200px]]
 
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==TOPOISOMERASE RESIDUES 410-1202,==
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The line below this paragraph, containing "STRUCTURE_1bgw", creates the "Structure Box" on the page.
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<StructureSection load='1bgw' size='340' side='right'caption='[[1bgw]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1bgw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. The January 2006 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Topoisomerases'' by David S. Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2006_1 10.2210/rcsb_pdb/mom_2006_1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BGW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1BGW FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1bgw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bgw OCA], [https://pdbe.org/1bgw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1bgw RCSB], [https://www.ebi.ac.uk/pdbsum/1bgw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1bgw ProSAT]</span></td></tr>
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{{STRUCTURE_1bgw| PDB=1bgw | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/TOP2_YEAST TOP2_YEAST] Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks. Essential during mitosis and meiosis for proper segregation of daughter chromosomes.<ref>PMID:9685374</ref> <ref>PMID:23022727</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bg/1bgw_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1bgw ConSurf].
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<div style="clear:both"></div>
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'''TOPOISOMERASE RESIDUES 410-1202,'''
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==See Also==
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*[[Topoisomerase 3D structures|Topoisomerase 3D structures]]
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== References ==
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==Overview==
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<references/>
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The crystal structure of a large fragment of yeast type II DNA topoisomerase reveals a heart-shaped dimeric protein with a large central hole. It provides a molecular model of the enzyme as an ATP-modulated clamp with two sets of jaws at opposite ends, connected by multiple joints. An enzyme with bound DNA can admit a second DNA duplex through one set of jaws, transport it through the cleaved first duplex, and expel it through the other set of jaws.
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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1BGW is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. The following page contains interesting information on the relation of 1BGW with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb73_1.html Topoisomerases]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BGW OCA].
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[[Category: RCSB PDB Molecule of the Month]]
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==Reference==
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Structure and mechanism of DNA topoisomerase II., Berger JM, Gamblin SJ, Harrison SC, Wang JC, Nature. 1996 Jan 18;379(6562):225-32. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8538787 8538787]
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[[Category: Saccharomyces cerevisiae]]
[[Category: Saccharomyces cerevisiae]]
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[[Category: Single protein]]
 
[[Category: Topoisomerases]]
[[Category: Topoisomerases]]
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[[Category: Berger, J M.]]
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[[Category: Berger JM]]
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[[Category: Gamblin, S J.]]
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[[Category: Gamblin SJ]]
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[[Category: Harrison, S C.]]
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[[Category: Harrison SC]]
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[[Category: Wang, J C.]]
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[[Category: Wang JC]]
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[[Category: Dna-binding]]
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[[Category: Isomerase]]
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[[Category: Phosphorylated nuclear protein]]
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[[Category: Topoisomerase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 11:29:46 2008''
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Current revision

TOPOISOMERASE RESIDUES 410-1202,

PDB ID 1bgw

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