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1bm9

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[[Image:1bm9.jpg|left|200px]]<br /><applet load="1bm9" size="350" color="white" frame="true" align="right" spinBox="true"
 
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caption="1bm9, resolution 2.00&Aring;" />
 
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'''REPLICATION TERMINATOR PROTEIN FROM BACILLUS SUBTILIS'''<br />
 
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==Overview==
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==REPLICATION TERMINATOR PROTEIN FROM BACILLUS SUBTILIS==
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The crystal structure of the replication terminator protein (RTP) of B. subtilis has been determined at 2.6 A resolution. As previously suggested by both biochemical and biophysical studies, the molecule exists as a symmetric dimer and is in the alpha + beta protein-folding class. The protein has several uncommon features, including an antiparallel coiled-coil, which serves as the dimerization domain, and both an alpha-helix and a beta-ribbon suitably positioned to interact with the major and minor grooves of B-DNA. A site has been identified on the surface of RTP that is biochemically and positionally suitable for interaction with the replication-specific helicase. Other features of the structure are consistent with the polar contrahelicase mechanism of the protein. A model of the interaction between RTP and its cognate DNA is presented.
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<StructureSection load='1bm9' size='340' side='right'caption='[[1bm9]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1bm9]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BM9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1BM9 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1bm9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bm9 OCA], [https://pdbe.org/1bm9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1bm9 RCSB], [https://www.ebi.ac.uk/pdbsum/1bm9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1bm9 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/RTP_BACSU RTP_BACSU] Plays a role in DNA replication and termination (fork arrest mechanism). Two dimers of rtp bind to the two inverted repeat regions (IRI and IRII) present in the termination site. The binding of each dimer is centered on an 8 bp direct repeat.
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==About this Structure==
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==See Also==
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1BM9 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BM9 OCA].
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*[[Replication Termination Protein|Replication Termination Protein]]
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__TOC__
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==Reference==
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</StructureSection>
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Crystal structure of the replication terminator protein from B. subtilis at 2.6 A., Bussiere DE, Bastia D, White SW, Cell. 1995 Feb 24;80(4):651-60. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=7867072 7867072]
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[[Category: Bacillus subtilis]]
[[Category: Bacillus subtilis]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Bastia, D.]]
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[[Category: Bastia D]]
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[[Category: Bussiere, D E.]]
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[[Category: Bussiere DE]]
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[[Category: White, S.]]
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[[Category: White S]]
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[[Category: contrahelicase]]
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[[Category: dna-binding protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 11:56:46 2008''
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Current revision

REPLICATION TERMINATOR PROTEIN FROM BACILLUS SUBTILIS

PDB ID 1bm9

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