1bqo

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(New page: 200px<br /> <applet load="1bqo" size="450" color="white" frame="true" align="right" spinBox="true" caption="1bqo, resolution 2.3&Aring;" /> '''DISCOVERY OF POTENT,...)
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[[Image:1bqo.gif|left|200px]]<br />
 
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<applet load="1bqo" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1bqo, resolution 2.3&Aring;" />
 
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'''DISCOVERY OF POTENT, ACHIRAL MATRIX METALLOPROTEINASE INHIBITORS'''<br />
 
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==Disease==
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==DISCOVERY OF POTENT, ACHIRAL MATRIX METALLOPROTEINASE INHIBITORS==
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Known diseases associated with this structure: Coronary heart disease, susceptibility to OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=185250 185250]]
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<StructureSection load='1bqo' size='340' side='right'caption='[[1bqo]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1bqo]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BQO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1BQO FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=N25:1,3-BIS-(4-METHOXY-BENZENESULFONYL)-5,5-DIMETHYL-HEXAHYDRO-PYRIMIDINE-2-CARBOXYLIC+ACID+HYDROXYAMIDE'>N25</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1bqo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bqo OCA], [https://pdbe.org/1bqo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1bqo RCSB], [https://www.ebi.ac.uk/pdbsum/1bqo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1bqo ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/MMP3_HUMAN MMP3_HUMAN] Defects in MMP3 are the cause of susceptibility to coronary heart disease type 6 (CHDS6) [MIM:[https://omim.org/entry/614466 614466]. A multifactorial disease characterized by an imbalance between myocardial functional requirements and the capacity of the coronary vessels to supply sufficient blood flow. Decreased capacity of the coronary vessels is often associated with thickening and loss of elasticity of the coronary arteries. Note=A polymorphism in the MMP3 promoter region is associated with the risk of coronary heart disease and myocardial infarction, due to lower MMP3 proteolytic activity and higher extracellular matrix deposition in atherosclerotic lesions.<ref>PMID:8662692</ref> <ref>PMID:12477941</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/MMP3_HUMAN MMP3_HUMAN] Can degrade fibronectin, laminin, gelatins of type I, III, IV, and V; collagens III, IV, X, and IX, and cartilage proteoglycans. Activates procollagenase.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bq/1bqo_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1bqo ConSurf].
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<div style="clear:both"></div>
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==About this Structure==
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==See Also==
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1BQO is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with ZN, CA and N25 as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Stromelysin_1 Stromelysin 1], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.17 3.4.24.17] Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1BQO OCA].
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*[[Matrix metalloproteinase 3D structures|Matrix metalloproteinase 3D structures]]
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== References ==
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==Reference==
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<references/>
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Discovery of potent, achiral matrix metalloproteinase inhibitors., Pikul S, McDow Dunham KL, Almstead NG, De B, Natchus MG, Anastasio MV, McPhail SJ, Snider CE, Taiwo YO, Rydel T, Dunaway CM, Gu F, Mieling GE, J Med Chem. 1998 Sep 10;41(19):3568-71. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9733482 9733482]
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Stromelysin 1]]
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[[Category: Almstead NG]]
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[[Category: Almstead, N.G.]]
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[[Category: Anastasio MV]]
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[[Category: Anastasio, M.V.]]
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[[Category: De B]]
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[[Category: De, B.]]
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[[Category: Dunaway CM]]
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[[Category: Dunaway, C.M.]]
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[[Category: Dunham KLM]]
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[[Category: Dunham, K.L.M.]]
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[[Category: Gu F]]
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[[Category: Gu, F.]]
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[[Category: Mcphail SJ]]
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[[Category: Mcphail, S.J.]]
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[[Category: Mieling GE]]
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[[Category: Mieling, G.E.]]
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[[Category: Natchus MG]]
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[[Category: Natchus, M.G.]]
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[[Category: Pikul S]]
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[[Category: Pikul, S.]]
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[[Category: Rydel TJ]]
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[[Category: Rydel, T.J.]]
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[[Category: Snider CE]]
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[[Category: Snider, C.E.]]
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[[Category: Taiwo YO]]
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[[Category: Taiwo, Y.O.]]
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[[Category: CA]]
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[[Category: N25]]
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[[Category: ZN]]
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[[Category: matrix metalloprotease]]
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[[Category: osteoarthritis]]
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[[Category: stromelysin]]
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[[Category: structure-based drug design]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 16:13:32 2007''
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Current revision

DISCOVERY OF POTENT, ACHIRAL MATRIX METALLOPROTEINASE INHIBITORS

PDB ID 1bqo

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