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1bxk

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==DTDP-GLUCOSE 4,6-DEHYDRATASE FROM E. COLI==
==DTDP-GLUCOSE 4,6-DEHYDRATASE FROM E. COLI==
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<StructureSection load='1bxk' size='340' side='right' caption='[[1bxk]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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<StructureSection load='1bxk' size='340' side='right'caption='[[1bxk]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1bxk]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BXK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1BXK FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1bxk]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BXK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1BXK FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/dTDP-glucose_4,6-dehydratase dTDP-glucose 4,6-dehydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.46 4.2.1.46] </span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1bxk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bxk OCA], [http://pdbe.org/1bxk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1bxk RCSB], [http://www.ebi.ac.uk/pdbsum/1bxk PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1bxk ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1bxk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bxk OCA], [https://pdbe.org/1bxk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1bxk RCSB], [https://www.ebi.ac.uk/pdbsum/1bxk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1bxk ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/RMLB2_ECOLI RMLB2_ECOLI]] Catalyzes the dehydration of dTDP-D-glucose to form dTDP-6-deoxy-D-xylo-4-hexulose via a three-step process involving oxidation, dehydration and reduction.<ref>PMID:7559340</ref>
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[https://www.uniprot.org/uniprot/RMLB2_ECOLI RMLB2_ECOLI] Catalyzes the dehydration of dTDP-D-glucose to form dTDP-6-deoxy-D-xylo-4-hexulose via a three-step process involving oxidation, dehydration and reduction.<ref>PMID:7559340</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bx/1bxk_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bx/1bxk_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
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==See Also==
==See Also==
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*[[InhA|InhA]]
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*[[DTDP-glucose 4%2C6-dehydratase|DTDP-glucose 4%2C6-dehydratase]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Bacillus coli migula 1895]]
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[[Category: Escherichia coli]]
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[[Category: DTDP-glucose 4,6-dehydratase]]
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[[Category: Large Structures]]
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[[Category: Frey, P A]]
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[[Category: Frey PA]]
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[[Category: Hegeman, A D]]
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[[Category: Hegeman AD]]
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[[Category: Holden, H M]]
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[[Category: Holden HM]]
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[[Category: Thoden, J B]]
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[[Category: Thoden JB]]
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[[Category: Dehydratase]]
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[[Category: Dehydrogenase]]
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[[Category: Epimerase]]
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[[Category: Lyase]]
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Current revision

DTDP-GLUCOSE 4,6-DEHYDRATASE FROM E. COLI

PDB ID 1bxk

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