This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1c25

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (06:40, 7 February 2024) (edit) (undo)
 
(7 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:1c25.png|left|200px]]
 
-
{{STRUCTURE_1c25| PDB=1c25 | SCENE= }}
+
==HUMAN CDC25A CATALYTIC DOMAIN==
-
 
+
<StructureSection load='1c25' size='340' side='right'caption='[[1c25]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
-
===HUMAN CDC25A CATALYTIC DOMAIN===
+
== Structural highlights ==
-
 
+
<table><tr><td colspan='2'>[[1c25]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1C25 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1C25 FirstGlance]. <br>
-
{{ABSTRACT_PUBMED_9604936}}
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
-
 
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1c25 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1c25 OCA], [https://pdbe.org/1c25 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1c25 RCSB], [https://www.ebi.ac.uk/pdbsum/1c25 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1c25 ProSAT]</span></td></tr>
-
==About this Structure==
+
</table>
-
[[1c25]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1C25 OCA].
+
== Function ==
 +
[https://www.uniprot.org/uniprot/MPIP1_HUMAN MPIP1_HUMAN] Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression. Directly dephosphorylates CDK1 and stimulates its kinase activity. Also dephosphorylates CDK2 in complex with cyclin E, in vitro.
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/c2/1c25_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1c25 ConSurf].
 +
<div style="clear:both"></div>
==See Also==
==See Also==
-
*[[Tyrosine phosphatase|Tyrosine phosphatase]]
+
*[[Tyrosine phosphatase 3D structures|Tyrosine phosphatase 3D structures]]
-
 
+
__TOC__
-
==Reference==
+
</StructureSection>
-
<ref group="xtra">PMID:009604936</ref><ref group="xtra">PMID:014695246</ref><ref group="xtra">PMID:015937284</ref><references group="xtra"/>
+
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Protein-tyrosine-phosphatase]]
+
[[Category: Large Structures]]
-
[[Category: Cogswell, J P.]]
+
[[Category: Cogswell JP]]
-
[[Category: Fauman, E B.]]
+
[[Category: Fauman EB]]
-
[[Category: Holmes, W.]]
+
[[Category: Holmes W]]
-
[[Category: Lovejoy, B.]]
+
[[Category: Lovejoy B]]
-
[[Category: Montana, V G.]]
+
[[Category: Montana VG]]
-
[[Category: Piwnica-Worms, H.]]
+
[[Category: Piwnica-Worms H]]
-
[[Category: Rink, M J.]]
+
[[Category: Rink MJ]]
-
[[Category: Rocque, W J.]]
+
[[Category: Rocque WJ]]
-
[[Category: Saper, M A.]]
+
[[Category: Saper MA]]
-
[[Category: Cdk2]]
+
-
[[Category: Cell cycle phosphatase]]
+
-
[[Category: Dual specificity protein phosphatase]]
+
-
[[Category: Hydrolase]]
+

Current revision

HUMAN CDC25A CATALYTIC DOMAIN

PDB ID 1c25

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1c25"
Personal tools