1c8z

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[[Image:1c8z.gif|left|200px]]
 
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{{Structure
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==C-TERMINAL DOMAIN OF MOUSE BRAIN TUBBY PROTEIN==
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|PDB= 1c8z |SIZE=350|CAPTION= <scene name='initialview01'>1c8z</scene>, resolution 1.9&Aring;
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<StructureSection load='1c8z' size='340' side='right'caption='[[1c8z]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=PO4:PHOSPHATE ION'>PO4</scene>
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<table><tr><td colspan='2'>[[1c8z]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1C8Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1C8Z FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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|GENE=
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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}}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1c8z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1c8z OCA], [https://pdbe.org/1c8z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1c8z RCSB], [https://www.ebi.ac.uk/pdbsum/1c8z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1c8z ProSAT]</span></td></tr>
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</table>
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'''C-TERMINAL DOMAIN OF MOUSE BRAIN TUBBY PROTEIN'''
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== Disease ==
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[https://www.uniprot.org/uniprot/TUB_MOUSE TUB_MOUSE] Note=Defects in Tub are the cause of maturity-onset obesity, insulin resistance and sensory deficits.
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== Function ==
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==Overview==
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[https://www.uniprot.org/uniprot/TUB_MOUSE TUB_MOUSE] Functions in signal transduction from heterotrimeric G protein-coupled receptors. Binds to membranes containing phosphatidylinositol 4,5-bisphosphate. Can bind DNA (in vitro). May contribute to the regulation of transcription in the nucleus. Could be involved in the hypothalamic regulation of body weight. Contribute to stimulation of phagocytosis of apoptotic retinal pigment epithelium (RPE) cells and macrophages (By similarity).<ref>PMID:10591637</ref> <ref>PMID:11375483</ref>
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Tubby-like proteins (TULPs) are found in a broad range of multicellular organisms. In mammals, genetic mutation of tubby or other TULPs can result in one or more of three disease phenotypes: obesity (from which the name "tubby" is derived), retinal degeneration, and hearing loss. These disease phenotypes indicate a vital role for tubby proteins; however, no biochemical function has yet been ascribed to any member of this protein family. A structure-directed approach was employed to investigate the biological function of these proteins. The crystal structure of the core domain from mouse tubby was determined at a resolution of 1.9 angstroms. From primarily structural clues, experiments were devised, the results of which suggest that TULPs are a unique family of bipartite transcription factors.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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==About this Structure==
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Check<jmol>
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1C8Z is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1C8Z OCA].
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/c8/1c8z_consurf.spt"</scriptWhenChecked>
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==Reference==
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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Implication of tubby proteins as transcription factors by structure-based functional analysis., Boggon TJ, Shan WS, Santagata S, Myers SC, Shapiro L, Science. 1999 Dec 10;286(5447):2119-25. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10591637 10591637]
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1c8z ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Single protein]]
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[[Category: Boggon TJ]]
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[[Category: Boggon, T J.]]
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[[Category: Myers SC]]
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[[Category: Myers, S C.]]
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[[Category: Shapiro L]]
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[[Category: Shapiro, L.]]
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[[Category: PO4]]
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[[Category: 12-stranded-beta-barrel]]
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[[Category: beta-barrel]]
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[[Category: deafness]]
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[[Category: filled-beta-roll]]
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[[Category: helix-filled-barrel]]
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[[Category: obesity blindness]]
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[[Category: tubby filled-barrel]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 10:21:24 2008''
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Current revision

C-TERMINAL DOMAIN OF MOUSE BRAIN TUBBY PROTEIN

PDB ID 1c8z

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