This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1cqp

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
m (Protected "1cqp" [edit=sysop:move=sysop])
Current revision (06:44, 7 February 2024) (edit) (undo)
 
(9 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:1cqp.png|left|200px]]
 
-
{{STRUCTURE_1cqp| PDB=1cqp | SCENE= }}
+
==CRYSTAL STRUCTURE ANALYSIS OF THE COMPLEX LFA-1 (CD11A) I-DOMAIN / LOVASTATIN AT 2.6 A RESOLUTION==
-
 
+
<StructureSection load='1cqp' size='340' side='right'caption='[[1cqp]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
-
===CRYSTAL STRUCTURE ANALYSIS OF THE COMPLEX LFA-1 (CD11A) I-DOMAIN / LOVASTATIN AT 2.6 A RESOLUTION===
+
== Structural highlights ==
-
 
+
<table><tr><td colspan='2'>[[1cqp]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CQP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1CQP FirstGlance]. <br>
-
{{ABSTRACT_PUBMED_10493852}}
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
-
 
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=803:LOVASTATIN'>803</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-
==About this Structure==
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1cqp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1cqp OCA], [https://pdbe.org/1cqp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1cqp RCSB], [https://www.ebi.ac.uk/pdbsum/1cqp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1cqp ProSAT]</span></td></tr>
-
[[1cqp]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CQP OCA].
+
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/ITAL_HUMAN ITAL_HUMAN] Integrin alpha-L/beta-2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. It is involved in a variety of immune phenomena including leukocyte-endothelial cell interaction, cytotoxic T-cell mediated killing, and antibody dependent killing by granulocytes and monocytes.
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cq/1cqp_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1cqp ConSurf].
 +
<div style="clear:both"></div>
==See Also==
==See Also==
-
*[[Integrin|Integrin]]
+
*[[Integrin 3D structures|Integrin 3D structures]]
-
 
+
__TOC__
-
==Reference==
+
</StructureSection>
-
<ref group="xtra">PMID:010493852</ref><references group="xtra"/>
+
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Cottens, S.]]
+
[[Category: Large Structures]]
-
[[Category: Geyl, D.]]
+
[[Category: Cottens S]]
-
[[Category: Hommel, U.]]
+
[[Category: Geyl D]]
-
[[Category: Kallen, J.]]
+
[[Category: Hommel U]]
-
[[Category: Kriwacki, R.]]
+
[[Category: Kallen J]]
-
[[Category: Legge, G.]]
+
[[Category: Kriwacki R]]
-
[[Category: Ramage, P.]]
+
[[Category: Legge G]]
-
[[Category: Weitz-Schmidt, G.]]
+
[[Category: Ramage P]]
-
[[Category: Welzenbach, K.]]
+
[[Category: Weitz-Schmidt G]]
-
[[Category: Immune system]]
+
[[Category: Welzenbach K]]
-
[[Category: Rossman fold]]
+
-
[[Category: Structural basis for lfa-1 inhibition]]
+

Current revision

CRYSTAL STRUCTURE ANALYSIS OF THE COMPLEX LFA-1 (CD11A) I-DOMAIN / LOVASTATIN AT 2.6 A RESOLUTION

PDB ID 1cqp

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1cqp"
Personal tools