1d3y

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[[Image:1d3y.gif|left|200px]]
 
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{{Structure
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==STRUCTURE OF THE DNA TOPOISOMERASE VI A SUBUNIT==
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|PDB= 1d3y |SIZE=350|CAPTION= <scene name='initialview01'>1d3y</scene>, resolution 2.0&Aring;
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<StructureSection load='1d3y' size='340' side='right'caption='[[1d3y]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>
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<table><tr><td colspan='2'>[[1d3y]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Methanocaldococcus_jannaschii Methanocaldococcus jannaschii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1D3Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1D3Y FirstGlance]. <br>
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA_topoisomerase_(ATP-hydrolyzing) DNA topoisomerase (ATP-hydrolyzing)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.99.1.3 5.99.1.3] </span>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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|GENE=
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
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|DOMAIN=
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1d3y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1d3y OCA], [https://pdbe.org/1d3y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1d3y RCSB], [https://www.ebi.ac.uk/pdbsum/1d3y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1d3y ProSAT]</span></td></tr>
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|RELATEDENTRY=
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</table>
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1d3y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1d3y OCA], [http://www.ebi.ac.uk/pdbsum/1d3y PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1d3y RCSB]</span>
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== Function ==
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}}
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[https://www.uniprot.org/uniprot/TOP6A_METJA TOP6A_METJA] Relaxes both positive and negative superturns and exhibits a strong decatenase activity.<ref>PMID:10545127</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/d3/1d3y_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1d3y ConSurf].
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<div style="clear:both"></div>
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'''STRUCTURE OF THE DNA TOPOISOMERASE VI A SUBUNIT'''
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==See Also==
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*[[Topoisomerase 3D structures|Topoisomerase 3D structures]]
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== References ==
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==Overview==
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<references/>
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In all organisms, type II DNA topoisomerases are essential for untangling chromosomal DNA. We have determined the structure of the DNA-binding core of the Methanococcus jannaschii DNA topoisomerase VI A subunit at 2.0 A resolution. The overall structure of this subunit is unique, demonstrating that archaeal type II enzymes are distinct from other type II topoisomerases. However, the core structure contains a pair of domains that are also found in type IA and classic type II topoisomerases. Together, these regions may form the basis of a DNA cleavage mechanism shared among these enzymes. The core A subunit is a dimer that contains a deep groove that spans both protomers. The dimer architecture suggests that DNA is bound in the groove, across the A subunit interface, and that the two monomers separate during DNA transport. The A subunit of topoisomerase VI is homologous to the meiotic recombination factor, Spo11, and this structure can serve as a template for probing Spo11 function in eukaryotes.
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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1D3Y is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Methanocaldococcus_jannaschii Methanocaldococcus jannaschii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1D3Y OCA].
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==Reference==
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Structure and function of an archaeal topoisomerase VI subunit with homology to the meiotic recombination factor Spo11., Nichols MD, DeAngelis K, Keck JL, Berger JM, EMBO J. 1999 Nov 1;18(21):6177-88. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10545127 10545127]
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[[Category: DNA topoisomerase (ATP-hydrolyzing)]]
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[[Category: Methanocaldococcus jannaschii]]
[[Category: Methanocaldococcus jannaschii]]
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[[Category: Single protein]]
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[[Category: Berger JM]]
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[[Category: Berger, J M.]]
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[[Category: DeAngelis KA]]
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[[Category: DeAngelis, K A.]]
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[[Category: Keck JL]]
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[[Category: Keck, J L.]]
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[[Category: Nichols MD]]
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[[Category: Nichols, M D.]]
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[[Category: dna binding protein]]
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[[Category: spo11 homolog]]
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[[Category: topoisomerase vi]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 19:34:10 2008''
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Current revision

STRUCTURE OF THE DNA TOPOISOMERASE VI A SUBUNIT

PDB ID 1d3y

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