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1d91

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==G.T BASE PAIRS IN A DNA HELIX. THE CRYSTAL STRUCTURE OF D(G-G-G-G-T-C-C-C)==
==G.T BASE PAIRS IN A DNA HELIX. THE CRYSTAL STRUCTURE OF D(G-G-G-G-T-C-C-C)==
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<StructureSection load='1d91' size='340' side='right' caption='[[1d91]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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<StructureSection load='1d91' size='340' side='right'caption='[[1d91]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1d91]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1D91 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1D91 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1d91]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1D91 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1D91 FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1d91 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1d91 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1d91 RCSB], [http://www.ebi.ac.uk/pdbsum/1d91 PDBsum]</span></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<table>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1d91 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1d91 OCA], [https://pdbe.org/1d91 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1d91 RCSB], [https://www.ebi.ac.uk/pdbsum/1d91 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1d91 ProSAT]</span></td></tr>
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<div style="background-color:#fffaf0;">
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</table>
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== Publication Abstract from PubMed ==
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The synthetic deoxyoctanucleotide d(G-G-G-G-T-C-C-C) crystallizes as an A-type DNA double helix containing two adjacent G . T base-pair mismatches. The structure has been refined to an R-factor of 14% at 2.1 A resolution with 104 solvent molecules located. The two G . T mismatches adopt the "wobble" form of base-pairing. The mismatched bases are linked by a network of water molecules interacting with the exposed functional groups in both the major and minor grooves. The presence of two mispaired bases in the octamer has surprisingly little effect on the global structure of the helix or the backbone and glycosidic torsional angles. Base stacking around the mismatch is perturbed, but the central G-T step shows particularly good base overlap, which may contribute to the relatively high stability of this oligomer.
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G . T base-pairs in a DNA helix: the crystal structure of d(G-G-G-G-T-C-C-C).,Kneale G, Brown T, Kennard O, Rabinovich D J Mol Biol. 1985 Dec 20;186(4):805-14. PMID:4093986<ref>PMID:4093986</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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== References ==
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<references/>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Brown, T.]]
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[[Category: Large Structures]]
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[[Category: Kennard, O.]]
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[[Category: Brown T]]
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[[Category: Kneale, G.]]
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[[Category: Kennard O]]
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[[Category: Rabinovich, D.]]
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[[Category: Kneale G]]
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[[Category: A-dna]]
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[[Category: Rabinovich D]]
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[[Category: Dna]]
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[[Category: Double helix]]
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[[Category: Mismatched]]
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Current revision

G.T BASE PAIRS IN A DNA HELIX. THE CRYSTAL STRUCTURE OF D(G-G-G-G-T-C-C-C)

PDB ID 1d91

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