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1da2

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[[Image:1da2.gif|left|200px]]
 
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==MOLECULAR AND CRYSTAL STRUCTURE OF D(CGCGMO4CG): N4-METHOXYCYTOSINE/GUANINE BASE-PAIRS IN Z-DNA==
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The line below this paragraph, containing "STRUCTURE_1da2", creates the "Structure Box" on the page.
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<StructureSection load='1da2' size='340' side='right'caption='[[1da2]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1da2]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DA2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1DA2 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=C45:N4-METHOXY-2-DEOXY-CYTIDINE-5-MONOPHOSPHATE'>C45</scene></td></tr>
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{{STRUCTURE_1da2| PDB=1da2 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1da2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1da2 OCA], [https://pdbe.org/1da2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1da2 RCSB], [https://www.ebi.ac.uk/pdbsum/1da2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1da2 ProSAT]</span></td></tr>
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</table>
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'''MOLECULAR AND CRYSTAL STRUCTURE OF D(CGCGMO4CG): N4-METHOXYCYTOSINE/GUANINE BASE-PAIRS IN Z-DNA'''
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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==Overview==
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[[Category: Brown DM]]
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The base analogue N4-methoxycytosine (mo4C) is ambivalent in its hydrogen-bonding potential, since it forms stable base-pairs with both adenine and guanine in oligomer duplexes. To investigate the base-pair geometry, the structure of d(CGCGmo4CG) has been determined by single-crystal X-ray diffraction techniques. The d(CGCGmo4CG)2 crystallized in a left-handed double helical structure (Z-type). Refinement using 2559 reflections between 10 and 1.7 A converged with a final R = 0.181 (Rw = 0.130) including 68 solvent molecules. The orthorhombic crystals are in the space group P2(1)2(1)2(1), with cell dimensions a = 18.17 A, b = 30.36 A, c = 43.93 A. The mo4C.G base-pair is of the wobble type, with mo4C in the imino form, and the methoxy group in the syn configuration.
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[[Category: Kennard O]]
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[[Category: Lin PKT]]
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==About this Structure==
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[[Category: Moore MH]]
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Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DA2 OCA].
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[[Category: Van Meervelt L]]
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==Reference==
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Molecular and crystal structure of d(CGCGmo4CG): N4-methoxycytosine.guanine base-pairs in Z-DNA., Van Meervelt L, Moore MH, Lin PK, Brown DM, Kennard O, J Mol Biol. 1990 Dec 5;216(3):773-81. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/2258939 2258939]
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[[Category: Brown, D M.]]
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[[Category: Kennard, O.]]
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[[Category: Lin, P K.T.]]
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[[Category: Meervelt, L Van.]]
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[[Category: Moore, M H.]]
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[[Category: Double helix]]
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[[Category: Modified]]
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[[Category: Z-dna]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 13:37:10 2008''
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Current revision

MOLECULAR AND CRYSTAL STRUCTURE OF D(CGCGMO4CG): N4-METHOXYCYTOSINE/GUANINE BASE-PAIRS IN Z-DNA

PDB ID 1da2

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