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1dg7

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[[Image:1dg7.png|left|200px]]
 
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{{STRUCTURE_1dg7| PDB=1dg7 | SCENE= }}
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==DIHYDROFOLATE REDUCTASE OF MYCOBACTERIUM TUBERCULOSIS COMPLEXED WITH NADPH AND 4-BROMO WR99210==
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<StructureSection load='1dg7' size='340' side='right'caption='[[1dg7]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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===DIHYDROFOLATE REDUCTASE OF MYCOBACTERIUM TUBERCULOSIS COMPLEXED WITH NADPH AND 4-BROMO WR99210===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1dg7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DG7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1DG7 FirstGlance]. <br>
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{{ABSTRACT_PUBMED_10623528}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene>, <scene name='pdbligand=WRB:1-[3-(4-BROMO-PHENOXY)-PROPOXY]-6,6-DIMETHYL-1.6-DIHYDRO-[1,3,5]TRIAZINE-2,4-DIAMINE'>WRB</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1dg7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dg7 OCA], [https://pdbe.org/1dg7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1dg7 RCSB], [https://www.ebi.ac.uk/pdbsum/1dg7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1dg7 ProSAT]</span></td></tr>
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[[1dg7]] is a 1 chain structure of [[Dihydrofolate reductase]] with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DG7 OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/DYR_MYCTU DYR_MYCTU] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dg/1dg7_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1dg7 ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Dihydrofolate reductase|Dihydrofolate reductase]]
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*[[Art:DHFR: A target for TB drugs|Art:DHFR: A target for TB drugs]]
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*[[Dihydrofolate reductase 3D structures|Dihydrofolate reductase 3D structures]]
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==Reference==
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__TOC__
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<ref group="xtra">PMID:010623528</ref><references group="xtra"/>
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</StructureSection>
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[[Category: Dihydrofolate reductase]]
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[[Category: Large Structures]]
[[Category: Mycobacterium tuberculosis]]
[[Category: Mycobacterium tuberculosis]]
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[[Category: Athappilly, F.]]
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[[Category: Athappilly F]]
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[[Category: Chitnumsub, P.]]
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[[Category: Chitnumsub P]]
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[[Category: Hol, W G.]]
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[[Category: Hol WG]]
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[[Category: Li, R.]]
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[[Category: Li R]]
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[[Category: Sirawaraporn, R.]]
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[[Category: Sirawaraporn R]]
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[[Category: Sirawaraporn, W.]]
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[[Category: Sirawaraporn W]]
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[[Category: Turley, S.]]
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[[Category: Turley S]]
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[[Category: Wooden, J.]]
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[[Category: Wooden J]]
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[[Category: Anti-malaria agent]]
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[[Category: Dihydrofolate reductase]]
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[[Category: Folateanalog]]
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[[Category: Nicotinamide adenine dinucleotide]]
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[[Category: Oxidoreductase]]
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[[Category: Rossmann fold]]
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[[Category: Structure-based inhibitor design]]
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[[Category: Tuberculosis]]
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[[Category: Wr99210]]
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Current revision

DIHYDROFOLATE REDUCTASE OF MYCOBACTERIUM TUBERCULOSIS COMPLEXED WITH NADPH AND 4-BROMO WR99210

PDB ID 1dg7

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