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1dgg

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{{STRUCTURE_1dgg| PDB=1dgg | SCENE= }}
 
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===HUMAN ERYTHROCYTE CATALSE CYANIDE COMPLEX===
 
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{{ABSTRACT_PUBMED_10656833}}
 
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==Disease==
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==HUMAN ERYTHROCYTE CATALSE CYANIDE COMPLEX==
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[[http://www.uniprot.org/uniprot/CATA_HUMAN CATA_HUMAN]] Defects in CAT are the cause of acatalasemia (ACATLAS) [MIM:[http://omim.org/entry/614097 614097]]. A metabolic disorder characterized by absence of catalase activity in red cells and is often associated with ulcerating oral lesions.<ref>PMID:2308162</ref>
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<StructureSection load='1dgg' size='340' side='right'caption='[[1dgg]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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== Structural highlights ==
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==Function==
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<table><tr><td colspan='2'>[[1dgg]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DGG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1DGG FirstGlance]. <br>
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[[http://www.uniprot.org/uniprot/CATA_HUMAN CATA_HUMAN]] Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Promotes growth of cells including T-cells, B-cells, myeloid leukemia cells, melanoma cells, mastocytoma cells and normal and transformed fibroblast cells.<ref>PMID:7882369</ref>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CYN:CYANIDE+ION'>CYN</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1dgg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dgg OCA], [https://pdbe.org/1dgg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1dgg RCSB], [https://www.ebi.ac.uk/pdbsum/1dgg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1dgg ProSAT]</span></td></tr>
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[[1dgg]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DGG OCA].
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/CATA_HUMAN CATA_HUMAN] Defects in CAT are the cause of acatalasemia (ACATLAS) [MIM:[https://omim.org/entry/614097 614097]. A metabolic disorder characterized by absence of catalase activity in red cells and is often associated with ulcerating oral lesions.<ref>PMID:2308162</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/CATA_HUMAN CATA_HUMAN] Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Promotes growth of cells including T-cells, B-cells, myeloid leukemia cells, melanoma cells, mastocytoma cells and normal and transformed fibroblast cells.<ref>PMID:7882369</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dg/1dgg_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1dgg ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Catalase|Catalase]]
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*[[Catalase 3D structures|Catalase 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:010656833</ref><references group="xtra"/><references/>
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__TOC__
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[[Category: Catalase]]
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Arvai, A S.]]
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[[Category: Large Structures]]
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[[Category: Bourne, Y.]]
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[[Category: Arvai AS]]
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[[Category: Putnam, C D.]]
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[[Category: Bourne Y]]
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[[Category: Tainer, J A.]]
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[[Category: Putnam CD]]
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[[Category: Catalase]]
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[[Category: Tainer JA]]
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[[Category: Cyanide]]
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[[Category: Heme]]
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[[Category: Hydrogen peroxide]]
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[[Category: Nadph]]
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[[Category: Oxidoreductase]]
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Current revision

HUMAN ERYTHROCYTE CATALSE CYANIDE COMPLEX

PDB ID 1dgg

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