1dir

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[[Image:1dir.gif|left|200px]]
 
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{{Structure
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==CRYSTAL STRUCTURE OF A MONOCLINIC FORM OF DIHYDROPTERIDINE REDUCTASE FROM RAT LIVER==
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|PDB= 1dir |SIZE=350|CAPTION= <scene name='initialview01'>1dir</scene>, resolution 2.60&Aring;
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<StructureSection load='1dir' size='340' side='right'caption='[[1dir]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene>
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<table><tr><td colspan='2'>[[1dir]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DIR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1DIR FirstGlance]. <br>
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/6,7-dihydropteridine_reductase 6,7-dihydropteridine reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.5.1.34 1.5.1.34] </span>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
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|GENE=
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>
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|DOMAIN=
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1dir FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dir OCA], [https://pdbe.org/1dir PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1dir RCSB], [https://www.ebi.ac.uk/pdbsum/1dir PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1dir ProSAT]</span></td></tr>
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|RELATEDENTRY=
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</table>
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1dir FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dir OCA], [http://www.ebi.ac.uk/pdbsum/1dir PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1dir RCSB]</span>
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== Function ==
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}}
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[https://www.uniprot.org/uniprot/DHPR_RAT DHPR_RAT] The product of this enzyme, tetrahydrobiopterin (BH-4), is an essential cofactor for phenylalanine, tyrosine, and tryptophan hydroxylases.
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== Evolutionary Conservation ==
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'''CRYSTAL STRUCTURE OF A MONOCLINIC FORM OF DIHYDROPTERIDINE REDUCTASE FROM RAT LIVER'''
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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==Overview==
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/di/1dir_consurf.spt"</scriptWhenChecked>
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A binary complex of dihydropteridine reductase and NADH crystallizes in the space group C2, with a = 222.2, b = 46.5, c = 95.3 A and beta = 101.1 degrees. There are two dimers in the asymmetric unit. The structure was solved by molecular-replacement techniques and refined with 2.6 A data to a crystallographic R factor of 16.8%. Each dimer has twofold non-crystallographic symmetry and the four individual monomers in the asymmetric unit have the same overall molecular conformation.
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==About this Structure==
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</jmolCheckbox>
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1DIR is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DIR OCA].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1dir ConSurf].
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<div style="clear:both"></div>
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==Reference==
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__TOC__
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Crystal structure of a monoclinic form of dihydropteridine reductase from rat liver., Su Y, Skinner MM, Xuong NH, Matthews DA, Whiteley JM, Varughese KI, Acta Crystallogr D Biol Crystallogr. 1994 Nov 1;50(Pt 6):884-8. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15299357 15299357]
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</StructureSection>
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[[Category: 6,7-dihydropteridine reductase]]
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[[Category: Large Structures]]
[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
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[[Category: Single protein]]
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[[Category: Matthews DA]]
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[[Category: Matthews, D A.]]
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[[Category: Skinner MM]]
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[[Category: Skinner, M M.]]
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[[Category: Su Y]]
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[[Category: Su, Y.]]
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[[Category: Varughese KI]]
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[[Category: Varughese, K I.]]
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[[Category: Whitely JM]]
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[[Category: Whitely, J M.]]
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[[Category: Xuong NH]]
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[[Category: Xuong, N H.]]
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[[Category: oxidoreductase(acting on nadh or nadph)]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 19:42:14 2008''
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Current revision

CRYSTAL STRUCTURE OF A MONOCLINIC FORM OF DIHYDROPTERIDINE REDUCTASE FROM RAT LIVER

PDB ID 1dir

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