This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1dn6

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (06:56, 7 February 2024) (edit) (undo)
 
(10 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:1dn6.gif|left|200px]]
 
-
<!--
+
==THE CRYSTAL STRUCTURE OF D(GGATGGGAG). AN ESSENTIAL PART OF THE BINDING SITE FOR TRANSCRIPTION FACTOR IIIA==
-
The line below this paragraph, containing "STRUCTURE_1dn6", creates the "Structure Box" on the page.
+
<StructureSection load='1dn6' size='340' side='right'caption='[[1dn6]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[1dn6]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DN6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1DN6 FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
-
-->
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1dn6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dn6 OCA], [https://pdbe.org/1dn6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1dn6 RCSB], [https://www.ebi.ac.uk/pdbsum/1dn6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1dn6 ProSAT]</span></td></tr>
-
{{STRUCTURE_1dn6| PDB=1dn6 | SCENE= }}
+
</table>
-
 
+
__TOC__
-
'''THE CRYSTAL STRUCTURE OF D(GGATGGGAG). AN ESSENTIAL PART OF THE BINDING SITE FOR TRANSCRIPTION FACTOR IIIA'''
+
</StructureSection>
-
 
+
[[Category: Large Structures]]
-
 
+
[[Category: Brown T]]
-
==Overview==
+
[[Category: Hunter WN]]
-
Most genes in higher organisms are activated by the binding of proteins called transcription factors. One such protein, transcription factor IIIA (TFIIIA) from the frog, activates the gene for 5S RNA by binding to the region of the gene between nucleotides 45 and 97. This binding site has been defined by a variety of biochemical studies, including base-deletion experiments and DNase I footprinting. The protein also binds to the gene product: in immature frogs it is stored as a complex with 5S RNA. From the observation that TFIIIA can bind to either double-helical DNA or RNA, and from their own measurements, Rhodes and Klug have proposed that the DNA-binding site for TFIIIA has an RNA-like structure. Here we present the crystal structure analysis of a part of the DNA-binding site (nucleotides 81-89 of the gene) which forms a particularly strong interaction with the protein, and show that it has a conformation similar to the A' form of double-helical RNA.
+
[[Category: Kennard O]]
-
 
+
[[Category: McCall M]]
-
==About this Structure==
+
-
Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DN6 OCA].
+
-
 
+
-
==Reference==
+
-
The crystal structure of d(GGATGGGAG): an essential part of the binding site for transcription factor IIIA., McCall M, Brown T, Hunter WN, Kennard O, Nature. 1986 Aug 14-20;322(6080):661-4. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/3748146 3748146]
+
-
[[Category: Brown, T.]]
+
-
[[Category: Hunter, W N.]]
+
-
[[Category: Kennard, O.]]
+
-
[[Category: McCall, M.]]
+
-
[[Category: A-dna]]
+
-
[[Category: Double helix]]
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 14:02:52 2008''
+

Current revision

THE CRYSTAL STRUCTURE OF D(GGATGGGAG). AN ESSENTIAL PART OF THE BINDING SITE FOR TRANSCRIPTION FACTOR IIIA

PDB ID 1dn6

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1dn6"
Personal tools