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1ds7

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{{Seed}}
 
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[[Image:1ds7.png|left|200px]]
 
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<!--
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==A MINOR FMN-DEPENDENT NITROREDUCTASE FROM ESCHERICHIA COLI B==
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The line below this paragraph, containing "STRUCTURE_1ds7", creates the "Structure Box" on the page.
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<StructureSection load='1ds7' size='340' side='right'caption='[[1ds7]], [[Resolution|resolution]] 2.06&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1ds7]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_B Escherichia coli B]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DS7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1DS7 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.06&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene></td></tr>
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{{STRUCTURE_1ds7| PDB=1ds7 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ds7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ds7 OCA], [https://pdbe.org/1ds7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ds7 RCSB], [https://www.ebi.ac.uk/pdbsum/1ds7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ds7 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/NFSB_ECOLI NFSB_ECOLI] Reduction of a variety of nitroaromatic compounds using NADH (and to lesser extent NADPH) as source of reducing equivalents; two electrons are transferred. Capable of reducing nitrofurazone, quinones and the anti-tumor agent CB1954 (5-(aziridin-1-yl)-2,4-dinitrobenzamide). The reduction of CB1954 results in the generation of cytotoxic species.<ref>PMID:15684426</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ds/1ds7_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ds7 ConSurf].
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<div style="clear:both"></div>
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===A MINOR FMN-DEPENDENT NITROREDUCTASE FROM ESCHERICHIA COLI B===
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==See Also==
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*[[Nitroreductase 3D structures|Nitroreductase 3D structures]]
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== References ==
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<references/>
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The line below this paragraph, {{ABSTRACT_PUBMED_11020276}}, adds the Publication Abstract to the page
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 11020276 is the PubMed ID number.
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</StructureSection>
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[[Category: Escherichia coli B]]
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{{ABSTRACT_PUBMED_11020276}}
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[[Category: Large Structures]]
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[[Category: Neidle S]]
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==About this Structure==
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[[Category: Parkinson G]]
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1DS7 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DS7 OCA].
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[[Category: Skelly J]]
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==Reference==
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Crystal structure of FMN-dependent nitroreductase from Escherichia coli B: a prodrug-activating enzyme., Parkinson GN, Skelly JV, Neidle S, J Med Chem. 2000 Oct 5;43(20):3624-31. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11020276 11020276]
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[[Category: 6,7-dihydropteridine reductase]]
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[[Category: Escherichia coli]]
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[[Category: Single protein]]
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[[Category: Neidle, S.]]
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[[Category: Parkinson, G.]]
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[[Category: Skelly, J.]]
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[[Category: Flavoprotein]]
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[[Category: Fmn]]
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[[Category: Nitroreductase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 23:32:20 2008''
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Current revision

A MINOR FMN-DEPENDENT NITROREDUCTASE FROM ESCHERICHIA COLI B

PDB ID 1ds7

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