1dto

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{{Seed}}
 
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[[Image:1dto.png|left|200px]]
 
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==CRYSTAL STRUCTURE OF THE COMPLETE TRANSACTIVATION DOMAIN OF E2 PROTEIN FROM THE HUMAN PAPILLOMAVIRUS TYPE 16==
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The line below this paragraph, containing "STRUCTURE_1dto", creates the "Structure Box" on the page.
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<StructureSection load='1dto' size='340' side='right'caption='[[1dto]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1dto]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_papillomavirus_type_16 Human papillomavirus type 16]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DTO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1DTO FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1dto FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dto OCA], [https://pdbe.org/1dto PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1dto RCSB], [https://www.ebi.ac.uk/pdbsum/1dto PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1dto ProSAT]</span></td></tr>
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{{STRUCTURE_1dto| PDB=1dto | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/VE2_HPV16 VE2_HPV16] Plays an accessory role in initiation of DNA replication. A dimer of E2 interacts with a dimer of E1 in order to improve specificity of E1 DNA binding activity. Once the complex recognizes and binds DNA at specific sites, the E2 dimer is removed from DNA. E2 also regulates viral transcription through binding to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory regions of the viral genome. Activates or represses transcription depending on E2RE's position with regards to proximal promoter elements including the TATA-box. Repression occurs by sterically hindering the assembly of the transcription initiation complex.<ref>PMID:3033289</ref> <ref>PMID:1326651</ref> <ref>PMID:15681049</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dt/1dto_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1dto ConSurf].
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<div style="clear:both"></div>
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===CRYSTAL STRUCTURE OF THE COMPLETE TRANSACTIVATION DOMAIN OF E2 PROTEIN FROM THE HUMAN PAPILLOMAVIRUS TYPE 16===
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==See Also==
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*[[Regulatory protein E2|Regulatory protein E2]]
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== References ==
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<references/>
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The line below this paragraph, {{ABSTRACT_PUBMED_10693813}}, adds the Publication Abstract to the page
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 10693813 is the PubMed ID number.
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</StructureSection>
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{{ABSTRACT_PUBMED_10693813}}
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==About this Structure==
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1DTO is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Human_papillomavirus_type_16 Human papillomavirus type 16]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DTO OCA].
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==Reference==
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Structure of the intact transactivation domain of the human papillomavirus E2 protein., Antson AA, Burns JE, Moroz OV, Scott DJ, Sanders CM, Bronstein IB, Dodson GG, Wilson KS, Maitland NJ, Nature. 2000 Feb 17;403(6771):805-9. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10693813 10693813]
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[[Category: Human papillomavirus type 16]]
[[Category: Human papillomavirus type 16]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Antson, A A.]]
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[[Category: Antson AA]]
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[[Category: Bronstein, I B.]]
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[[Category: Bronstein IB]]
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[[Category: Burns, J E.]]
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[[Category: Burns JE]]
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[[Category: Dodson, G G.]]
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[[Category: Dodson GG]]
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[[Category: Maitland, N.]]
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[[Category: Maitland N]]
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[[Category: Moroz, O V.]]
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[[Category: Moroz OV]]
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[[Category: Sanders, C M.]]
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[[Category: Sanders CM]]
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[[Category: Scott, D J.]]
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[[Category: Scott DJ]]
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[[Category: Wilson, K S.]]
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[[Category: Wilson KS]]
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[[Category: Beta-sheet]]
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[[Category: Three-helix bundle]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 23:36:01 2008''
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Current revision

CRYSTAL STRUCTURE OF THE COMPLETE TRANSACTIVATION DOMAIN OF E2 PROTEIN FROM THE HUMAN PAPILLOMAVIRUS TYPE 16

PDB ID 1dto

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