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1edh

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[[Image:1edh.png|left|200px]]
 
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{{STRUCTURE_1edh| PDB=1edh | SCENE= }}
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==E-CADHERIN DOMAINS 1 AND 2 IN COMPLEX WITH CALCIUM==
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<StructureSection load='1edh' size='340' side='right'caption='[[1edh]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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===E-CADHERIN DOMAINS 1 AND 2 IN COMPLEX WITH CALCIUM===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1edh]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EDH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1EDH FirstGlance]. <br>
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{{ABSTRACT_PUBMED_8598933}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=HG:MERCURY+(II)+ION'>HG</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1edh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1edh OCA], [https://pdbe.org/1edh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1edh RCSB], [https://www.ebi.ac.uk/pdbsum/1edh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1edh ProSAT]</span></td></tr>
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[[1edh]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EDH OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CADH1_MOUSE CADH1_MOUSE] Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells. Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7 (By similarity). E-Cad/CTF2 promotes non-amyloidogenic degradation of Abeta precursors. Has a strong inhibitory effect on APP C99 and C83 production (By similarity).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ed/1edh_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1edh ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Cadherin|Cadherin]]
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*[[Cadherin 3D structures|Cadherin 3D structures]]
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__TOC__
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==Reference==
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</StructureSection>
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<ref group="xtra">PMID:008598933</ref><ref group="xtra">PMID:016980367</ref><references group="xtra"/>
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[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Ikura, M.]]
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[[Category: Ikura M]]
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[[Category: Nagar, B.]]
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[[Category: Nagar B]]
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[[Category: Overduin, M.]]
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[[Category: Overduin M]]
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[[Category: Rini, J M.]]
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[[Category: Rini JM]]
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[[Category: Cadherin]]
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[[Category: Calcium binding protein]]
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[[Category: Cell adhesion protein]]
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Current revision

E-CADHERIN DOMAINS 1 AND 2 IN COMPLEX WITH CALCIUM

PDB ID 1edh

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