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1ee8

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[[Image:1ee8.png|left|200px]]
 
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{{STRUCTURE_1ee8| PDB=1ee8 | SCENE= }}
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==CRYSTAL STRUCTURE OF MUTM (FPG) PROTEIN FROM THERMUS THERMOPHILUS HB8==
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<StructureSection load='1ee8' size='340' side='right'caption='[[1ee8]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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===CRYSTAL STRUCTURE OF MUTM (FPG) PROTEIN FROM THERMUS THERMOPHILUS HB8===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1ee8]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermus_thermophilus_HB8 Thermus thermophilus HB8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EE8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1EE8 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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==About this Structure==
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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[[1ee8]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermus_thermophilus_hb8 Thermus thermophilus hb8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EE8 OCA].
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ee8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ee8 OCA], [https://pdbe.org/1ee8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ee8 RCSB], [https://www.ebi.ac.uk/pdbsum/1ee8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ee8 ProSAT], [https://www.topsan.org/Proteins/RSGI/1ee8 TOPSAN]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/FPG_THET8 FPG_THET8] Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ee/1ee8_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ee8 ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[DNA repair protein human endonuclease VIII-like 1 (NEIL1)|DNA repair protein human endonuclease VIII-like 1 (NEIL1)]]
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*[[DNA glycosylase 3D structures|DNA glycosylase 3D structures]]
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*[[Fpg Nei Protein Family|Fpg Nei Protein Family]]
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__TOC__
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*[[Fpg Nei Protein Superfamily|Fpg Nei Protein Superfamily]]
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</StructureSection>
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[[Category: Large Structures]]
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==Reference==
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[[Category: Thermus thermophilus HB8]]
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<ref group="xtra">PMID:010921868</ref><references group="xtra"/>
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[[Category: Fukuyama K]]
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[[Category: Thermus thermophilus hb8]]
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[[Category: Inoue Y]]
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[[Category: Fukuyama, K.]]
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[[Category: Kato R]]
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[[Category: Inoue, Y.]]
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[[Category: Kumasaka T]]
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[[Category: Kato, R.]]
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[[Category: Kuramitsu S]]
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[[Category: Kumasaka, T.]]
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[[Category: Mikawa T]]
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[[Category: Kuramitsu, S.]]
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[[Category: Sugahara M]]
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[[Category: Mikawa, T.]]
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[[Category: Yamamoto M]]
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[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
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[[Category: Sugahara, M.]]
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[[Category: Yamamoto, M.]]
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[[Category: Beta sandwich]]
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[[Category: Dna binding protein]]
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[[Category: Helix two-turns helix]]
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[[Category: Riken structural genomics/proteomics initiative]]
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[[Category: Rsgi]]
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[[Category: Structural genomic]]
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[[Category: Zinc finger]]
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Current revision

CRYSTAL STRUCTURE OF MUTM (FPG) PROTEIN FROM THERMUS THERMOPHILUS HB8

PDB ID 1ee8

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