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1efd

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[[Image:1efd.gif|left|200px]]
 
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==PERIPLASMIC FERRIC SIDEROPHORE BINDING PROTEIN FHUD COMPLEXED WITH GALLICHROME==
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The line below this paragraph, containing "STRUCTURE_1efd", creates the "Structure Box" on the page.
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<StructureSection load='1efd' size='340' side='right'caption='[[1efd]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1efd]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EFD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1EFD FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GCR:GALLICHROME'>GCR</scene></td></tr>
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{{STRUCTURE_1efd| PDB=1efd | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1efd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1efd OCA], [https://pdbe.org/1efd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1efd RCSB], [https://www.ebi.ac.uk/pdbsum/1efd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1efd ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/FHUD_ECOLI FHUD_ECOLI] Part of the ABC transporter complex FhuCDB involved in iron(3+)-hydroxamate import. Binds the iron(3+)-hydroxamate complex and transfers it to the membrane-bound permease. Required for the transport of all iron(3+)-hydroxamate siderophores such as ferrichrome, gallichrome, desferrioxamine, coprogen, aerobactin, shizokinen, rhodotorulic acid and the antibiotic albomycin.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ef/1efd_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1efd ConSurf].
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<div style="clear:both"></div>
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'''PERIPLASMIC FERRIC SIDEROPHORE BINDING PROTEIN FHUD COMPLEXED WITH GALLICHROME'''
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==See Also==
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*[[Ferric hydroxamate uptake receptor|Ferric hydroxamate uptake receptor]]
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__TOC__
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==Overview==
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</StructureSection>
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Siderophore binding proteins play a key role in the uptake of iron in many gram-positive and gram-negative bacteria. FhuD is a soluble periplasmic binding protein that transports ferrichrome and other hydroxamate siderophores. The crystal structure of FhuD from Escherichia coli in complex with the ferrichrome homolog gallichrome has been determined at 1.9 inverted question mark resolution, the first structure of a periplasmic binding protein involved in the uptake of siderophores. Gallichrome is held in a shallow pocket lined with aromatic groups; Arg and Tyr side chains interact directly with the hydroxamate moieties of the siderophore. FhuD possesses a novel fold, suggesting that its mechanisms of ligand binding and release are different from other structurally characterized periplasmic ligand binding proteins.
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==About this Structure==
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1EFD is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EFD OCA].
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==Reference==
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The structure of the ferric siderophore binding protein FhuD complexed with gallichrome., Clarke TE, Ku SY, Dougan DR, Vogel HJ, Tari LW, Nat Struct Biol. 2000 Apr;7(4):287-91. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10742172 10742172]
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[[Category: Escherichia coli]]
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[[Category: Single protein]]
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[[Category: Clarke, T E.]]
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[[Category: Dougan, D R.]]
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[[Category: Ku, S Y.]]
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[[Category: Tari, L W.]]
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[[Category: Vogel, H J.]]
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[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
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[[Category: Ferric siderophore binding protein]]
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[[Category: Large Structures]]
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[[Category: Fhud complex with gallichrome]]
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[[Category: Clarke TE]]
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[[Category: Periplasmic binding protein-siderophore complex]]
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[[Category: Dougan DR]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 15:01:45 2008''
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[[Category: Ku S-Y]]
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[[Category: Tari LW]]
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[[Category: Vogel HJ]]

Current revision

PERIPLASMIC FERRIC SIDEROPHORE BINDING PROTEIN FHUD COMPLEXED WITH GALLICHROME

PDB ID 1efd

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