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1egk

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[[Image:1egk.gif|left|200px]]
 
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{{Structure
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==CRYSTAL STRUCTURE OF A NUCLEIC ACID FOUR-WAY JUNCTION==
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|PDB= 1egk |SIZE=350|CAPTION= <scene name='initialview01'>1egk</scene>, resolution 3.1&Aring;
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<StructureSection load='1egk' size='340' side='right'caption='[[1egk]], [[Resolution|resolution]] 3.10&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=A:ADENOSINE-5&#39;-MONOPHOSPHATE'>A</scene>, <scene name='pdbligand=C:CYTIDINE-5&#39;-MONOPHOSPHATE'>C</scene>, <scene name='pdbligand=DA:2&#39;-DEOXYADENOSINE-5&#39;-MONOPHOSPHATE'>DA</scene>, <scene name='pdbligand=DC:2&#39;-DEOXYCYTIDINE-5&#39;-MONOPHOSPHATE'>DC</scene>, <scene name='pdbligand=DG:2&#39;-DEOXYGUANOSINE-5&#39;-MONOPHOSPHATE'>DG</scene>, <scene name='pdbligand=DT:THYMIDINE-5&#39;-MONOPHOSPHATE'>DT</scene>, <scene name='pdbligand=G:GUANOSINE-5&#39;-MONOPHOSPHATE'>G</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=U:URIDINE-5&#39;-MONOPHOSPHATE'>U</scene>
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<table><tr><td colspan='2'>[[1egk]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EGK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1EGK FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.1&#8491;</td></tr>
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|GENE=
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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|DOMAIN=
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1egk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1egk OCA], [https://pdbe.org/1egk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1egk RCSB], [https://www.ebi.ac.uk/pdbsum/1egk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1egk ProSAT]</span></td></tr>
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|RELATEDENTRY=[[1br3|1BR3]]
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</table>
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1egk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1egk OCA], [http://www.ebi.ac.uk/pdbsum/1egk PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1egk RCSB]</span>
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__TOC__
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}}
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</StructureSection>
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[[Category: Large Structures]]
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'''CRYSTAL STRUCTURE OF A NUCLEIC ACID FOUR-WAY JUNCTION'''
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[[Category: Joyce GF]]
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[[Category: Nowakowski J]]
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[[Category: Shim PJ]]
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==Overview==
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[[Category: Stout CD]]
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A crystal structure of a 108 nucleotide RNA-DNA complex containing a four-way junction was solved at 3.1 A resolution. The structure of the junction differs substantially from the "stacked-X" conformation observed previously, due to a 135 degrees rotation of the branches. Comparison of the two conformers provides insight into the factors contributing to the flexibility of four-way junctions. The stacked-X conformation maximizes base-stacking but causes unfavorable repulsion between phosphate groups, whereas the 135 degrees -rotated "crossed" conformation minimizes electrostatic clashes at the expense of reduced base-stacking. Despite the large rotation of the branches, both junction structures exhibit an antiparallel arrangement of the continuous strands and opposite polarity of the crossover strands.
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==About this Structure==
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1EGK is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EGK OCA].
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==Reference==
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Alternative conformations of a nucleic acid four-way junction., Nowakowski J, Shim PJ, Stout CD, Joyce GF, J Mol Biol. 2000 Jun 30;300(1):93-102. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10864501 10864501]
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[[Category: Protein complex]]
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[[Category: Joyce, G F.]]
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[[Category: Nowakowski, J.]]
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[[Category: Shim, P J.]]
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[[Category: Stout, C D.]]
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[[Category: 10-23 dna enzyme]]
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[[Category: four-way junction]]
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[[Category: nucleic acid]]
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[[Category: ribozyme]]
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[[Category: rna-dna complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 20:02:08 2008''
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Current revision

CRYSTAL STRUCTURE OF A NUCLEIC ACID FOUR-WAY JUNCTION

PDB ID 1egk

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