1egk

<StructureSection load='1egk' size='340' side='right' caption='[[1egk]], [[Resolution|resolution]] 3.10&Aring;' scene=''>

<table><tr><td colspan='2'>[[1egk]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EGK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1EGK FirstGlance]. <br>

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>

<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1br3|1br3]]</td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1egk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1egk OCA], [http://pdbe.org/1egk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1egk RCSB], [http://www.ebi.ac.uk/pdbsum/1egk PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1egk ProSAT]</span></td></tr>

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== Publication Abstract from PubMed ==

A crystal structure of a 108 nucleotide RNA-DNA complex containing a four-way junction was solved at 3.1 A resolution. The structure of the junction differs substantially from the "stacked-X" conformation observed previously, due to a 135 degrees rotation of the branches. Comparison of the two conformers provides insight into the factors contributing to the flexibility of four-way junctions. The stacked-X conformation maximizes base-stacking but causes unfavorable repulsion between phosphate groups, whereas the 135 degrees -rotated "crossed" conformation minimizes electrostatic clashes at the expense of reduced base-stacking. Despite the large rotation of the branches, both junction structures exhibit an antiparallel arrangement of the continuous strands and opposite polarity of the crossover strands.

Alternative conformations of a nucleic acid four-way junction.,Nowakowski J, Shim PJ, Stout CD, Joyce GF J Mol Biol. 2000 Jun 30;300(1):93-102. PMID:10864501<ref>PMID:10864501</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>

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<div class="pdbe-citations 1egk" style="background-color:#fffaf0;"></div>

== References ==

<references/>

[[Category: Joyce, G F]]

[[Category: Nowakowski, J]]

[[Category: Shim, P J]]

[[Category: Stout, C D]]

[[Category: 10-23 dna enzyme]]

[[Category: Rna-dna complex]]