1ei6

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[[Image:1ei6.gif|left|200px]]
 
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{{Structure
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==CRYSTAL STRUCTURE OF PHOSPHONOACETATE HYDROLASE COMPLEXED WITH PHOSPHONOFORMATE==
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|PDB= 1ei6 |SIZE=350|CAPTION= <scene name='initialview01'>1ei6</scene>, resolution 2.1&Aring;
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<StructureSection load='1ei6' size='340' side='right'caption='[[1ei6]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=PPF:PHOSPHONOFORMIC+ACID'>PPF</scene>, <scene name='pdbligand=TLA:L(+)-TARTARIC+ACID'>TLA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
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<table><tr><td colspan='2'>[[1ei6]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_fluorescens Pseudomonas fluorescens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EI6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1EI6 FirstGlance]. <br>
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphonoacetate_hydrolase Phosphonoacetate hydrolase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.11.1.2 3.11.1.2] </span>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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|GENE=
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PPF:PHOSPHONOFORMIC+ACID'>PPF</scene>, <scene name='pdbligand=TLA:L(+)-TARTARIC+ACID'>TLA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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|DOMAIN=
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ei6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ei6 OCA], [https://pdbe.org/1ei6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ei6 RCSB], [https://www.ebi.ac.uk/pdbsum/1ei6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ei6 ProSAT]</span></td></tr>
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|RELATEDENTRY=
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</table>
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ei6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ei6 OCA], [http://www.ebi.ac.uk/pdbsum/1ei6 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1ei6 RCSB]</span>
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== Function ==
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}}
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[https://www.uniprot.org/uniprot/PHNHY_PSEFL PHNHY_PSEFL] Specifically hydrolyzes phosphonoacetate. Does not have activity on other organophosphonates or acetates.<ref>PMID:8288524</ref>
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== Evolutionary Conservation ==
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'''CRYSTAL STRUCTURE OF PHOSPHONOACETATE HYDROLASE COMPLEXED WITH PHOSPHONOFORMATE'''
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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==About this Structure==
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ei/1ei6_consurf.spt"</scriptWhenChecked>
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1EI6 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Pseudomonas_fluorescens Pseudomonas fluorescens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EI6 OCA].
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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[[Category: Phosphonoacetate hydrolase]]
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ei6 ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Pseudomonas fluorescens]]
[[Category: Pseudomonas fluorescens]]
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[[Category: Single protein]]
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[[Category: Benning MM]]
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[[Category: Benning, M M.]]
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[[Category: Dunaway-Mariano D]]
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[[Category: Dunaway-Mariano, D.]]
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[[Category: Holden HM]]
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[[Category: Holden, H M.]]
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[[Category: Kim AD]]
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[[Category: Kim, A D.]]
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[[Category: crystal structure]]
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[[Category: hydrolase]]
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[[Category: phosphonoacetate]]
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[[Category: zinc]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 20:03:02 2008''
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Current revision

CRYSTAL STRUCTURE OF PHOSPHONOACETATE HYDROLASE COMPLEXED WITH PHOSPHONOFORMATE

PDB ID 1ei6

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