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1ej4

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{{Seed}}
 
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[[Image:1ej4.png|left|200px]]
 
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==COCRYSTAL STRUCTURE OF EIF4E/4E-BP1 PEPTIDE==
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The line below this paragraph, containing "STRUCTURE_1ej4", creates the "Structure Box" on the page.
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<StructureSection load='1ej4' size='340' side='right'caption='[[1ej4]], [[Resolution|resolution]] 2.25&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1ej4]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EJ4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1EJ4 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.25&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=M7G:7N-METHYL-8-HYDROGUANOSINE-5-DIPHOSPHATE'>M7G</scene></td></tr>
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{{STRUCTURE_1ej4| PDB=1ej4 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ej4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ej4 OCA], [https://pdbe.org/1ej4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ej4 RCSB], [https://www.ebi.ac.uk/pdbsum/1ej4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ej4 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/IF4E_MOUSE IF4E_MOUSE] Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. May play an important role in spermatogenesis through translational regulation of stage-specific mRNAs during germ cell development (By similarity). Its translation stimulation activity is repressed by binding to the complex CYFIP1-FMR1. Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit mediates the binding to the mRNA cap.<ref>PMID:18805096</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ej/1ej4_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ej4 ConSurf].
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<div style="clear:both"></div>
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===COCRYSTAL STRUCTURE OF EIF4E/4E-BP1 PEPTIDE===
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==See Also==
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*[[Eukaryotic initiation factor 3D structures|Eukaryotic initiation factor 3D structures]]
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== References ==
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<references/>
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 10394359 is the PubMed ID number.
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</StructureSection>
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[[Category: Homo sapiens]]
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{{ABSTRACT_PUBMED_10394359}}
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[[Category: Large Structures]]
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==About this Structure==
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1EJ4 is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EJ4 OCA].
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==Reference==
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<ref group="xtra">PMID:10394359</ref><references group="xtra"/>
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[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Burley, S K.]]
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[[Category: Burley SK]]
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[[Category: Gingras, A C.]]
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[[Category: Gingras A-C]]
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[[Category: Marcotrigiano, J.]]
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[[Category: Marcotrigiano J]]
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[[Category: Sonenberg, N.]]
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[[Category: Sonenberg N]]
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[[Category: Eif4e/4e-bp/7-methyl-gdp]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 03:53:56 2009''
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Current revision

COCRYSTAL STRUCTURE OF EIF4E/4E-BP1 PEPTIDE

PDB ID 1ej4

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