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1ejh

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[[Image:1ejh.jpg|left|200px]]
 
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{{Structure
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==EIF4E/EIF4G PEPTIDE/7-METHYL-GDP==
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|PDB= 1ejh |SIZE=350|CAPTION= <scene name='initialview01'>1ejh</scene>, resolution 2.2&Aring;
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<StructureSection load='1ejh' size='340' side='right'caption='[[1ejh]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=M7G:7N-METHYL-8-HYDROGUANOSINE-5&#39;-DIPHOSPHATE'>M7G</scene>
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<table><tr><td colspan='2'>[[1ejh]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EJH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1EJH FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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|GENE=
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=M7G:7N-METHYL-8-HYDROGUANOSINE-5-DIPHOSPHATE'>M7G</scene></td></tr>
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|DOMAIN=
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ejh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ejh OCA], [https://pdbe.org/1ejh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ejh RCSB], [https://www.ebi.ac.uk/pdbsum/1ejh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ejh ProSAT]</span></td></tr>
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|RELATEDENTRY=[[1ej1|1EJ1]], [[1ej4|1EJ4]]
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</table>
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ejh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ejh OCA], [http://www.ebi.ac.uk/pdbsum/1ejh PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1ejh RCSB]</span>
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== Function ==
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}}
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[https://www.uniprot.org/uniprot/IF4E_MOUSE IF4E_MOUSE] Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. May play an important role in spermatogenesis through translational regulation of stage-specific mRNAs during germ cell development (By similarity). Its translation stimulation activity is repressed by binding to the complex CYFIP1-FMR1. Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit mediates the binding to the mRNA cap.<ref>PMID:18805096</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ej/1ejh_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ejh ConSurf].
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<div style="clear:both"></div>
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'''EIF4E/EIF4G PEPTIDE/7-METHYL-GDP'''
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==See Also==
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*[[Eukaryotic initiation factor 3D structures|Eukaryotic initiation factor 3D structures]]
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== References ==
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==Overview==
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<references/>
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eIF4G uses a conserved Tyr-X-X-X-X-Leu-phi segment (where X is variable and phi is hydrophobic) to recognize eIF4E during cap-dependent translation initiation in eukaryotes. High-resolution X-ray crystallography and complementary biophysical methods have revealed that this eIF4E recognition motif undergoes a disorder-to-order transition, adopting an L-shaped, extended chain/alpha-helical conformation when it interacts with a phylogenetically invariant portion of the convex surface of eIF4E. Inhibitors of translation initiation known as eIF4E-binding proteins (4E-BPs) contain similar eIF4E recognition motifs. These molecules are molecular mimics of eIF4G, which act by occupying the same binding site on the convex dorsum of eIF4E and blocking assembly of the translation machinery. The implications of our results for translation initiation are discussed in detail, and a molecular mechanism for relief of translation inhibition following phosphorylation of the 4E-BPs is proposed.
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Homo sapiens]]
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1EJH is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EJH OCA].
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[[Category: Large Structures]]
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==Reference==
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Cap-dependent translation initiation in eukaryotes is regulated by a molecular mimic of eIF4G., Marcotrigiano J, Gingras AC, Sonenberg N, Burley SK, Mol Cell. 1999 Jun;3(6):707-16. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10394359 10394359]
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[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Protein complex]]
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[[Category: Burley SK]]
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[[Category: Burley, S K.]]
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[[Category: Gingras A-C]]
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[[Category: Gingras, A C.]]
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[[Category: Marcotrigiano J]]
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[[Category: Marcotrigiano, J.]]
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[[Category: Sonenberg N]]
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[[Category: Sonenberg, N.]]
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[[Category: eif4e/eif4gii peptide/7-methyl-gdp]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 20:03:49 2008''
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Current revision

EIF4E/EIF4G PEPTIDE/7-METHYL-GDP

PDB ID 1ejh

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