1ek2

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[[Image:1ek2.png|left|200px]]
 
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==CRYSTAL STRUCTURE OF MURINE SOLUBLE EPOXIDE HYDROLASE COMPLEXED WITH CDU INHIBITOR==
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The line below this paragraph, containing "STRUCTURE_1ek2", creates the "Structure Box" on the page.
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<StructureSection load='1ek2' size='340' side='right'caption='[[1ek2]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1ek2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EK2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1EK2 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CDU:N-CYCLOHEXYL-N-DECYLUREA'>CDU</scene></td></tr>
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{{STRUCTURE_1ek2| PDB=1ek2 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ek2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ek2 OCA], [https://pdbe.org/1ek2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ek2 RCSB], [https://www.ebi.ac.uk/pdbsum/1ek2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ek2 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/HYES_MOUSE HYES_MOUSE] Bifunctional enzyme. The C-terminal domain has epoxide hydrolase activity and acts on epoxides (alkene oxides, oxiranes) and arene oxides. Plays a role in xenobiotic metabolism by degrading potentially toxic epoxides. Also determines steady-state levels of physiological mediators. The N-terminal domain has lipid phosphatase activity, with the highest activity towards threo-9,10-phosphonooxy-hydroxy-octadecanoic acid, followed by erythro-9,10-phosphonooxy-hydroxy-octadecanoic acid, 12-phosphonooxy-octadec-9Z-enoic acid, 12-phosphonooxy-octadec-9E-enoic acid, and p-nitrophenyl phospate (By similarity).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ek/1ek2_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ek2 ConSurf].
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<div style="clear:both"></div>
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===CRYSTAL STRUCTURE OF MURINE SOLUBLE EPOXIDE HYDROLASE COMPLEXED WITH CDU INHIBITOR===
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==See Also==
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*[[Epoxide hydrolase 3D structures|Epoxide hydrolase 3D structures]]
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 10747889 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10747889}}
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==About this Structure==
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1EK2 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EK2 OCA].
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==Reference==
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Binding of alkylurea inhibitors to epoxide hydrolase implicates active site tyrosines in substrate activation., Argiriadi MA, Morisseau C, Goodrow MH, Dowdy DL, Hammock BD, Christianson DW, J Biol Chem. 2000 May 19;275(20):15265-70. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10747889 10747889]
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[[Category: Microsomal epoxide hydrolase]]
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[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Single protein]]
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[[Category: Argiriadi MA]]
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[[Category: Argiriadi, M A.]]
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[[Category: Christianson DW]]
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[[Category: Christianson, D W.]]
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[[Category: Dowdy DL]]
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[[Category: Dowdy, D L.]]
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[[Category: Goodrow MH]]
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[[Category: Goodrow, M H.]]
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[[Category: Hammock BD]]
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[[Category: Hammock, B D.]]
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[[Category: Morisseau C]]
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[[Category: Morisseau, C.]]
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[[Category: Alpha/beta hydrolase fold]]
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[[Category: Disubstituted urea inhibitor]]
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[[Category: Homodimer]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 00:52:26 2008''
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Current revision

CRYSTAL STRUCTURE OF MURINE SOLUBLE EPOXIDE HYDROLASE COMPLEXED WITH CDU INHIBITOR

PDB ID 1ek2

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