1es6
From Proteopedia
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| - | [[Image:1es6.png|left|200px]] | ||
| - | + | ==CRYSTAL STRUCTURE OF THE MATRIX PROTEIN OF EBOLA VIRUS== | |
| - | + | <StructureSection load='1es6' size='340' side='right'caption='[[1es6]], [[Resolution|resolution]] 2.00Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[1es6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Ebola_virus_sp. Ebola virus sp.]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ES6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ES6 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2Å</td></tr> | |
| - | == | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1es6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1es6 OCA], [https://pdbe.org/1es6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1es6 RCSB], [https://www.ebi.ac.uk/pdbsum/1es6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1es6 ProSAT]</span></td></tr> |
| - | [[1es6]] is a 1 chain structure with sequence from [ | + | </table> |
| - | + | == Function == | |
| - | + | [https://www.uniprot.org/uniprot/VP40_EBOZ5 VP40_EBOZ5] Plays an essential role virus particle assembly and budding. Acts by interacting with viral ribonucleocapsid and host members of the ESCRT (endosomal sorting complex required for transport) system such as host VPS4, PDCD6IP/ALIX, NEDD4 or TGS101. The interaction with host E3 ubiquitin ligase SMURF2 also facilitates virus budding. May play a role in immune cell dysfunction by being packaged into exosomes that can decrease the viability of recipient cells (via RNAi suppression and exosome-bystander apoptosis).[UniProtKB:Q05128] | |
| - | < | + | __TOC__ |
| - | [[ | + | </StructureSection> |
| - | [ | + | [[Category: Ebola virus sp]] |
| - | [ | + | [[Category: Large Structures]] |
| - | [ | + | [[Category: Dessen A]] |
| - | [[Category: | + | [[Category: Dolnik O]] |
| - | [[Category: | + | [[Category: Klenk H-D]] |
| - | [[Category: | + | [[Category: Volchkov V]] |
| - | [[Category: | + | [[Category: Weissenhorn W]] |
| - | [[Category: | + | |
| - | [[Category: | + | |
| - | [[Category: | + | |
Current revision
CRYSTAL STRUCTURE OF THE MATRIX PROTEIN OF EBOLA VIRUS
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