1es6

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[[Image:1es6.jpg|left|200px]]
 
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{{Structure
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==CRYSTAL STRUCTURE OF THE MATRIX PROTEIN OF EBOLA VIRUS==
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|PDB= 1es6 |SIZE=350|CAPTION= <scene name='initialview01'>1es6</scene>, resolution 2.0&Aring;
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<StructureSection load='1es6' size='340' side='right'caption='[[1es6]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND=
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<table><tr><td colspan='2'>[[1es6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Ebola_virus_sp. Ebola virus sp.]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ES6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ES6 FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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|GENE=
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1es6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1es6 OCA], [https://pdbe.org/1es6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1es6 RCSB], [https://www.ebi.ac.uk/pdbsum/1es6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1es6 ProSAT]</span></td></tr>
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|DOMAIN=
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</table>
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|RELATEDENTRY=
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== Function ==
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1es6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1es6 OCA], [http://www.ebi.ac.uk/pdbsum/1es6 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1es6 RCSB]</span>
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[https://www.uniprot.org/uniprot/VP40_EBOZ5 VP40_EBOZ5] Plays an essential role virus particle assembly and budding. Acts by interacting with viral ribonucleocapsid and host members of the ESCRT (endosomal sorting complex required for transport) system such as host VPS4, PDCD6IP/ALIX, NEDD4 or TGS101. The interaction with host E3 ubiquitin ligase SMURF2 also facilitates virus budding. May play a role in immune cell dysfunction by being packaged into exosomes that can decrease the viability of recipient cells (via RNAi suppression and exosome-bystander apoptosis).[UniProtKB:Q05128]
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}}
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__TOC__
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</StructureSection>
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'''CRYSTAL STRUCTURE OF THE MATRIX PROTEIN OF EBOLA VIRUS'''
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[[Category: Ebola virus sp]]
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[[Category: Large Structures]]
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[[Category: Dessen A]]
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==Overview==
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[[Category: Dolnik O]]
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Ebola virus maturation occurs at the plasma membrane of infected cells and involves the clustering of the viral matrix protein VP40 at the assembly site as well as its interaction with the lipid bilayer. Here we report the X-ray crystal structure of VP40 from Ebola virus at 2.0 A resolution. The crystal structure reveals that Ebola virus VP40 is topologically distinct from all other known viral matrix proteins, consisting of two domains with unique folds, connected by a flexible linker. The C-terminal domain, which is absolutely required for membrane binding, contains large hydrophobic patches that may be involved in the interaction with lipid bilayers. Likewise, a highly basic region is shared between the two domains. The crystal structure reveals how the molecule may be able to switch from a monomeric conformation to a hexameric form, as observed in vitro. Its implications for the assembly process are discussed.
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[[Category: Klenk H-D]]
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[[Category: Volchkov V]]
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==About this Structure==
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[[Category: Weissenhorn W]]
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1ES6 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Ebola_virus_sp. Ebola virus sp.]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ES6 OCA].
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==Reference==
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Crystal structure of the matrix protein VP40 from Ebola virus., Dessen A, Volchkov V, Dolnik O, Klenk HD, Weissenhorn W, EMBO J. 2000 Aug 15;19(16):4228-36. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10944105 10944105]
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[[Category: Ebola virus sp.]]
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[[Category: Single protein]]
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[[Category: Dessen, A.]]
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[[Category: Dolnik, O.]]
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[[Category: Klenk, H D.]]
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[[Category: Volchkov, V.]]
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[[Category: Weissenhorn, W.]]
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[[Category: anti-parallel strand]]
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[[Category: beta sandwich]]
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[[Category: beta sheet]]
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[[Category: helix]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 20:08:36 2008''
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Current revision

CRYSTAL STRUCTURE OF THE MATRIX PROTEIN OF EBOLA VIRUS

PDB ID 1es6

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