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1es9

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{{Seed}}
 
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[[Image:1es9.png|left|200px]]
 
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==X-RAY CRYSTAL STRUCTURE OF R22K MUTANT OF THE MAMMALIAN BRAIN PLATELET-ACTIVATING FACTOR ACETYLHYDROLASES (PAF-AH)==
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The line below this paragraph, containing "STRUCTURE_1es9", creates the "Structure Box" on the page.
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<StructureSection load='1es9' size='340' side='right'caption='[[1es9]], [[Resolution|resolution]] 1.30&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1es9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ES9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ES9 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.3&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1es9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1es9 OCA], [https://pdbe.org/1es9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1es9 RCSB], [https://www.ebi.ac.uk/pdbsum/1es9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1es9 ProSAT]</span></td></tr>
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{{STRUCTURE_1es9| PDB=1es9 | SCENE= }}
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</table>
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== Function ==
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===X-RAY CRYSTAL STRUCTURE OF R22K MUTANT OF THE MAMMALIAN BRAIN PLATELET-ACTIVATING FACTOR ACETYLHYDROLASES (PAF-AH)===
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[https://www.uniprot.org/uniprot/PA1B3_BOVIN PA1B3_BOVIN] Inactivates paf by removing the acetyl group at the sn-2 position. This is a catalytic subunit. Plays an important role during the development of brain.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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The line below this paragraph, {{ABSTRACT_PUBMED_11239086}}, adds the Publication Abstract to the page
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<jmolCheckbox>
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(as it appears on PubMed at http://www.pubmed.gov), where 11239086 is the PubMed ID number.
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/es/1es9_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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{{ABSTRACT_PUBMED_11239086}}
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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==About this Structure==
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1es9 ConSurf].
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1ES9 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ES9 OCA].
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<div style="clear:both"></div>
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__TOC__
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==Reference==
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</StructureSection>
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The functional implications of the dimerization of the catalytic subunits of the mammalian brain platelet-activating factor acetylhydrolase (Ib)., McMullen TW, Li J, Sheffield PJ, Aoki J, Martin TW, Arai H, Inoue K, Derewenda ZS, Protein Eng. 2000 Dec;13(12):865-71. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11239086 11239086]
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[[Category: 1-alkyl-2-acetylglycerophosphocholine esterase]]
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[[Category: Bos taurus]]
[[Category: Bos taurus]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Aoki, J.]]
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[[Category: Aoki J]]
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[[Category: Arai, H.]]
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[[Category: Arai H]]
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[[Category: Derewenda, Z S.]]
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[[Category: Derewenda ZS]]
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[[Category: Inoue, K.]]
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[[Category: Inoue K]]
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[[Category: Li, J.]]
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[[Category: Li J]]
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[[Category: Martin, T W.]]
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[[Category: Martin TW]]
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[[Category: McMullen, T W.P.]]
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[[Category: McMullen TWP]]
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[[Category: Sheffield, P J.]]
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[[Category: Sheffield PJ]]
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[[Category: Alpha/beta hydrolase fold]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 01:47:55 2008''
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Current revision

X-RAY CRYSTAL STRUCTURE OF R22K MUTANT OF THE MAMMALIAN BRAIN PLATELET-ACTIVATING FACTOR ACETYLHYDROLASES (PAF-AH)

PDB ID 1es9

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