1ezf

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{{Seed}}
 
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[[Image:1ezf.png|left|200px]]
 
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==CRYSTAL STRUCTURE OF HUMAN SQUALENE SYNTHASE==
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The line below this paragraph, containing "STRUCTURE_1ezf", creates the "Structure Box" on the page.
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<StructureSection load='1ezf' size='340' side='right'caption='[[1ezf]], [[Resolution|resolution]] 2.15&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1ezf]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EZF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1EZF FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.15&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IN0:N-{2-[TRANS-7-CHLORO-1-(2,2-DIMETHYL-PROPYL)+-5-NAPHTHALEN-1-YL-2-OXO-1,2,3,5-TETRAHYDRO-BENZO[E]+[1,4]OXAZEPIN-3-YL]-ACETYL}-ASPARTIC+ACID'>IN0</scene></td></tr>
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{{STRUCTURE_1ezf| PDB=1ezf | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ezf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ezf OCA], [https://pdbe.org/1ezf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ezf RCSB], [https://www.ebi.ac.uk/pdbsum/1ezf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ezf ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/FDFT_HUMAN FDFT_HUMAN]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ez/1ezf_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ezf ConSurf].
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<div style="clear:both"></div>
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===CRYSTAL STRUCTURE OF HUMAN SQUALENE SYNTHASE===
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==See Also==
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*[[Squalene synthase|Squalene synthase]]
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__TOC__
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</StructureSection>
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The line below this paragraph, {{ABSTRACT_PUBMED_10896663}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 10896663 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10896663}}
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==About this Structure==
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1EZF is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EZF OCA].
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==Reference==
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Crystal structure of human squalene synthase. A key enzyme in cholesterol biosynthesis., Pandit J, Danley DE, Schulte GK, Mazzalupo S, Pauly TA, Hayward CM, Hamanaka ES, Thompson JF, Harwood HJ Jr, J Biol Chem. 2000 Sep 29;275(39):30610-7. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10896663 10896663]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Squalene synthase]]
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[[Category: Danley DE]]
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[[Category: Danley, D E.]]
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[[Category: Hamanaka ES]]
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[[Category: Hamanaka, E S.]]
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[[Category: Harwood HJ]]
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[[Category: Harwood, H J.]]
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[[Category: Hayward CM]]
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[[Category: Hayward, C M.]]
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[[Category: Mazzalupo SM]]
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[[Category: Mazzalupo, S M.]]
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[[Category: Pandit J]]
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[[Category: Pandit, J.]]
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[[Category: Pauly TA]]
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[[Category: Pauly, T A.]]
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[[Category: Schulte GK]]
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[[Category: Schulte, G K.]]
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[[Category: Thompson JF]]
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[[Category: Thompson, J F.]]
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[[Category: All alpha-helix]]
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[[Category: Isoprenoid synthase fold]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 02:15:07 2008''
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Current revision

CRYSTAL STRUCTURE OF HUMAN SQUALENE SYNTHASE

PDB ID 1ezf

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