1f15

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
(New page: 200px<br /><applet load="1f15" size="450" color="white" frame="true" align="right" spinBox="true" caption="1f15, resolution 3.2&Aring;" /> '''CUCUMBER MOSAIC VIRUS...)
Current revision (07:09, 7 February 2024) (edit) (undo)
 
(16 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:1f15.gif|left|200px]]<br /><applet load="1f15" size="450" color="white" frame="true" align="right" spinBox="true"
 
-
caption="1f15, resolution 3.2&Aring;" />
 
-
'''CUCUMBER MOSAIC VIRUS (STRAIN FNY)'''<br />
 
-
==Overview==
+
==CUCUMBER MOSAIC VIRUS (STRAIN FNY)==
-
The structure of cucumber mosaic virus (CMV; strain Fny) has been, determined to a 3.2-A resolution using X-ray crystallography. Despite the, fact that CMV has only 19% capsid protein sequence identity (34%, similarity) to cowpea chlorotic mottle virus (CCMV), the core structures, of these two members of the Bromoviridae family are highly homologous. As, suggested by a previous low-resolution structural study, the 305-A, diameter (maximum) of CMV is approximately 12 A larger than that of CCMV., In CCMV, the structures of the A, B, and C subunits are nearly identical, except in their N termini. In contrast, the structures of two loops in, subunit A of CMV differ from those in B and C. These loops are 6 and 7, residues longer than the analogous regions in CCMV. Unlike that of CCMV, the capsid of CMV does not undergo swelling at pH 7.0 and is stable at pH, 9.0. This may be partly due to the fact that the N termini of the B and C, subunits form a unique bundle of six amphipathic helices oriented down, into the virion core at the threefold axes. In addition, while CCMV has a, cluster of aspartic acid residues at the quasi-threefold axis that are, proposed to bind metal in a pH-dependent manner, this cluster is replaced, by complementing acids and bases in CMV. Finally, this structure clearly, demonstrates that the residues important for aphid transmission lie at the, outermost portion of the betaH-betaI loop and yields details of the, portions of the virus that are hypothesized to mediate binding to aphid, mouthparts.
+
<StructureSection load='1f15' size='340' side='right'caption='[[1f15]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
 +
== Structural highlights ==
 +
<table><tr><td colspan='2'>[[1f15]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Cucumber_mosaic_virus_(strain_FNY) Cucumber mosaic virus (strain FNY)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1F15 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1F15 FirstGlance]. <br>
 +
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.2&#8491;</td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1f15 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1f15 OCA], [https://pdbe.org/1f15 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1f15 RCSB], [https://www.ebi.ac.uk/pdbsum/1f15 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1f15 ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/CAPSD_CMVFN CAPSD_CMVFN] Capsid protein. Probably binds RNA and plays a role in packaging (By similarity).
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/f1/1f15_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1f15 ConSurf].
 +
<div style="clear:both"></div>
-
==About this Structure==
+
==See Also==
-
1F15 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Cucumber_mosaic_virus Cucumber mosaic virus]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1F15 OCA].
+
*[[Virus coat proteins 3D structures|Virus coat proteins 3D structures]]
-
 
+
__TOC__
-
==Reference==
+
</StructureSection>
-
The structure of cucumber mosaic virus and comparison to cowpea chlorotic mottle virus., Smith TJ, Chase E, Schmidt T, Perry KL, J Virol. 2000 Aug;74(16):7578-86. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=10906212 10906212]
+
[[Category: Large Structures]]
-
[[Category: Cucumber mosaic virus]]
+
[[Category: Chase E]]
-
[[Category: Single protein]]
+
[[Category: Perry K]]
-
[[Category: Chase, E.]]
+
[[Category: Schmidt T]]
-
[[Category: Perry, K.]]
+
[[Category: Smith TJ]]
-
[[Category: Schmidt, T.]]
+
-
[[Category: Smith, T.J.]]
+
-
[[Category: beta barrel]]
+
-
[[Category: icosahedral virus]]
+
-
[[Category: virus]]
+
-
 
+
-
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Nov 20 14:31:02 2007''
+

Current revision

CUCUMBER MOSAIC VIRUS (STRAIN FNY)

PDB ID 1f15

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1f15"
Personal tools