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1f21

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[[Image:1f21.png|left|200px]]
 
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{{STRUCTURE_1f21| PDB=1f21 | SCENE= }}
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==DIVALENT METAL COFACTOR BINDING IN THE KINETIC FOLDING TRAJECTORY OF E. COLI RIBONUCLEASE HI==
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<StructureSection load='1f21' size='340' side='right'caption='[[1f21]], [[Resolution|resolution]] 1.40&Aring;' scene=''>
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===DIVALENT METAL COFACTOR BINDING IN THE KINETIC FOLDING TRAJECTORY OF E. COLI RIBONUCLEASE HI===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1f21]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1F21 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1F21 FirstGlance]. <br>
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{{ABSTRACT_PUBMED_11106164}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.4&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1f21 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1f21 OCA], [https://pdbe.org/1f21 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1f21 RCSB], [https://www.ebi.ac.uk/pdbsum/1f21 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1f21 ProSAT]</span></td></tr>
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==About this Structure==
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</table>
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[[1f21]] is a 1 chain structure of [[Ribonuclease]] with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1F21 OCA].
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== Function ==
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[https://www.uniprot.org/uniprot/RNH_ECOLI RNH_ECOLI] Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. RNase H participates in DNA replication; it helps to specify the origin of genomic replication by suppressing initiation at origins other than the oriC locus; along with the 5'-3' exonuclease of pol1, it removes RNA primers from the Okazaki fragments of lagging strand synthesis; and it defines the origin of replication for ColE1-type plasmids by specific cleavage of an RNA preprimer.[HAMAP-Rule:MF_00042]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/f2/1f21_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1f21 ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Ribonuclease|Ribonuclease]]
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*[[Ribonuclease 3D structures|Ribonuclease 3D structures]]
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__TOC__
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==Reference==
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</StructureSection>
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<ref group="xtra">PMID:011106164</ref><references group="xtra"/>
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[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
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[[Category: Ribonuclease H]]
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[[Category: Large Structures]]
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[[Category: Berger, J M.]]
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[[Category: Berger JM]]
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[[Category: Goedken, E R.]]
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[[Category: Goedken ER]]
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[[Category: Keck, J L.]]
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[[Category: Keck JL]]
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[[Category: Marqusee, S.]]
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[[Category: Marqusee S]]
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[[Category: Hydrolase]]
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[[Category: Metal-binding protein]]
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[[Category: Nuclease]]
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[[Category: Protein folding]]
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[[Category: Ribnuclease h]]
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[[Category: Rnase h]]
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[[Category: Rnase h*]]
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Current revision

DIVALENT METAL COFACTOR BINDING IN THE KINETIC FOLDING TRAJECTORY OF E. COLI RIBONUCLEASE HI

PDB ID 1f21

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