1f5t

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{{Seed}}
 
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[[Image:1f5t.png|left|200px]]
 
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==DIPHTHERIA TOX REPRESSOR (C102D MUTANT) COMPLEXED WITH NICKEL AND DTXR CONSENSUS BINDING SEQUENCE==
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The line below this paragraph, containing "STRUCTURE_1f5t", creates the "Structure Box" on the page.
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<StructureSection load='1f5t' size='340' side='right'caption='[[1f5t]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1f5t]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Corynebacterium_diphtheriae Corynebacterium diphtheriae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1F5T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1F5T FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr>
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{{STRUCTURE_1f5t| PDB=1f5t | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1f5t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1f5t OCA], [https://pdbe.org/1f5t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1f5t RCSB], [https://www.ebi.ac.uk/pdbsum/1f5t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1f5t ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/DTXR_CORDI DTXR_CORDI] Iron-binding repressor of the dipheteria toxin gene expression. May serve as a global regulator of gene expression. Represses ripA under iron excess.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/f5/1f5t_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1f5t ConSurf].
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<div style="clear:both"></div>
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===DIPHTHERIA TOX REPRESSOR (C102D MUTANT) COMPLEXED WITH NICKEL AND DTXR CONSENSUS BINDING SEQUENCE===
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==See Also==
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*[[Diphtheria toxin repressor|Diphtheria toxin repressor]]
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__TOC__
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</StructureSection>
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The line below this paragraph, {{ABSTRACT_PUBMED_10956029}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 10956029 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10956029}}
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==About this Structure==
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1F5T is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Corynebacterium_diphtheriae Corynebacterium diphtheriae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1F5T OCA].
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==Reference==
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Methyl groups of thymine bases are important for nucleic acid recognition by DtxR., Chen CS, White A, Love J, Murphy JR, Ringe D, Biochemistry. 2000 Aug 29;39(34):10397-407. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10956029 10956029]
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[[Category: Corynebacterium diphtheriae]]
[[Category: Corynebacterium diphtheriae]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Chen, S.]]
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[[Category: Chen S]]
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[[Category: Love, J.]]
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[[Category: Love J]]
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[[Category: Murphy, J R.]]
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[[Category: Murphy JR]]
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[[Category: Ringe, D.]]
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[[Category: Ringe D]]
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[[Category: White, A.]]
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[[Category: White A]]
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[[Category: Diphtheria tox repressor]]
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[[Category: Dna-binding regulatory protein]]
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[[Category: Dna-protein complex]]
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[[Category: Helix-turn-helix motif]]
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[[Category: Iron-regulated repressor]]
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[[Category: Transcription regulator]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 02:44:39 2008''
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Current revision

DIPHTHERIA TOX REPRESSOR (C102D MUTANT) COMPLEXED WITH NICKEL AND DTXR CONSENSUS BINDING SEQUENCE

PDB ID 1f5t

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