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1fcw

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TRNA POSITIONS DURING THE ELONGATION CYCLE

1fcw, resolution 17.00Å

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-[[Image:1fcw.gif|left|200px]]<br /><applet load="1fcw" size="450" color="white" frame="true" align="right" spinBox="true"
-caption="1fcw, resolution 17.0&Aring;" />
-'''TRNA POSITIONS DURING THE ELONGATION CYCLE'''<br />
-==Overview==
+==TRNA POSITIONS DURING THE ELONGATION CYCLE==
-Three-dimensional cryomaps have been reconstructed for tRNA-ribosome, complexes in pre- and posttranslocational states at 17-A resolution. The, positions of tRNAs in the A and P sites in the pretranslocational, complexes and in the P and E sites in the posttranslocational complexes, have been determined. Of these, the P-site tRNA position is the same as, seen earlier in the initiation-like fMet-tRNA(f)(Met)-ribosome complex, where it was visualized with high accuracy. Now, the positions of the A-, and E-site tRNAs are determined with similar accuracy. The positions of, the CCA end of the tRNAs at the A site are different before and after, peptide bond formation. The relative positions of anticodons of P- and, E-site tRNAs in the posttranslocational state are such that a, codon-anticodon interaction at the E site appears feasible.
+<SX load='1fcw' size='340' side='right' viewer='molstar' caption='[[1fcw]], [[Resolution|resolution]] 17.00&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[1fcw]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FCW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1FCW FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 17&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1MA:6-HYDRO-1-METHYLADENOSINE-5-MONOPHOSPHATE'>1MA</scene>, <scene name='pdbligand=2MG:2N-METHYLGUANOSINE-5-MONOPHOSPHATE'>2MG</scene>, <scene name='pdbligand=5MC:5-METHYLCYTIDINE-5-MONOPHOSPHATE'>5MC</scene>, <scene name='pdbligand=5MU:5-METHYLURIDINE+5-MONOPHOSPHATE'>5MU</scene>, <scene name='pdbligand=7MG:7N-METHYL-8-HYDROGUANOSINE-5-MONOPHOSPHATE'>7MG</scene>, <scene name='pdbligand=H2U:5,6-DIHYDROURIDINE-5-MONOPHOSPHATE'>H2U</scene>, <scene name='pdbligand=M2G:N2-DIMETHYLGUANOSINE-5-MONOPHOSPHATE'>M2G</scene>, <scene name='pdbligand=OMC:O2-METHYLYCYTIDINE-5-MONOPHOSPHATE'>OMC</scene>, <scene name='pdbligand=OMG:O2-METHYLGUANOSINE-5-MONOPHOSPHATE'>OMG</scene>, <scene name='pdbligand=PSU:PSEUDOURIDINE-5-MONOPHOSPHATE'>PSU</scene>, <scene name='pdbligand=YG:WYBUTOSINE'>YG</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1fcw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fcw OCA], [https://pdbe.org/1fcw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1fcw RCSB], [https://www.ebi.ac.uk/pdbsum/1fcw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1fcw ProSAT]</span></td></tr>
+</table>
-==About this Structure==
+==See Also==
-FCW is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1FCW OCA].
+*[[Transfer RNA (tRNA)|Transfer RNA (tRNA)]]
+__TOC__
-==Reference==
+</SX>
-Visualization of tRNA movements on the Escherichia coli 70S ribosome during the elongation cycle., Agrawal RK, Spahn CM, Penczek P, Grassucci RA, Nierhaus KH, Frank J, J Cell Biol. 2000 Aug 7;150(3):447-60. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=10931859 10931859]
+[[Category: Large Structures]]
-[[Category: Protein complex]]
 [[Category: Saccharomyces cerevisiae]]
-[[Category: Agrawal, R.K.]]
+[[Category: Agrawal RK]]
-[[Category: Frank, J.]]
+[[Category: Frank J]]
-[[Category: Grassucci, R.A.]]
+[[Category: Grassucci RA]]
-[[Category: Nierhaus, K.H.]]
+[[Category: Nierhaus KH]]
-[[Category: Penczek, P.]]
+[[Category: Penczek P]]
-[[Category: Spahn, C.M.T.]]
+[[Category: Spahn CMT]]
-[[Category: cryo-electron microscopy]]
-[[Category: elongation cycle]]
-[[Category: protein synthesis]]
-[[Category: ribosome]]
-[[Category: trna binding sites]]
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Sat Nov 24 23:39:48 2007''

1fcw

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TRNA POSITIONS DURING THE ELONGATION CYCLE

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