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1feu

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(New page: 200px<br /><applet load="1feu" size="450" color="white" frame="true" align="right" spinBox="true" caption="1feu, resolution 2.3&Aring;" /> '''CRYSTAL STRUCTURE OF ...)
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[[Image:1feu.gif|left|200px]]<br /><applet load="1feu" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1feu, resolution 2.3&Aring;" />
 
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'''CRYSTAL STRUCTURE OF RIBOSOMAL PROTEIN TL5, ONE OF THE CTC FAMILY PROTEINS, COMPLEXED WITH A FRAGMENT OF 5S RRNA.'''<br />
 
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==Overview==
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==CRYSTAL STRUCTURE OF RIBOSOMAL PROTEIN TL5, ONE OF THE CTC FAMILY PROTEINS, COMPLEXED WITH A FRAGMENT OF 5S RRNA.==
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The crystal structure of Thermus thermophilus ribosomal protein TL5 in, complex with a fragment of Escherichia coli 5S rRNA has been determined at, 2.3 A resolution. The protein consists of two domains. The structure of, the N-terminal domain is close to the structure of E. coli ribosomal, protein L25, but the C-terminal domain represents a new fold composed of, seven beta-strands connected by long loops. TL5 binds to the RNA through, its N-terminal domain, whereas the C-terminal domain is not included in, this interaction. Cd(2+) ions, the presence of which improved the crystal, quality significantly, bind only to the protein component of the complex, and stabilize the protein molecule itself and the interactions between the, two molecules in the asymmetric unit of the crystal. The TL5 sequence, reveals homology to the so-called general stress protein CTC. The, hydrophobic cores which stabilize both TL5 domains are highly conserved in, CTC proteins. Thus, all CTC proteins may fold with a topology close to, that of TL5.
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<StructureSection load='1feu' size='340' side='right'caption='[[1feu]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1feu]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FEU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1FEU FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1feu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1feu OCA], [https://pdbe.org/1feu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1feu RCSB], [https://www.ebi.ac.uk/pdbsum/1feu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1feu ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/RL25_THETH RL25_THETH] This is one of 3 proteins that mediate the attachment of the 5S rRNA onto the large ribosomal subunit.<ref>PMID:10356982</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fe/1feu_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1feu ConSurf].
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<div style="clear:both"></div>
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==About this Structure==
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==See Also==
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1FEU is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus] with CD and MG as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1FEU OCA].
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*[[Ribosomal protein L25|Ribosomal protein L25]]
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== References ==
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==Reference==
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<references/>
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Structure of ribosomal protein TL5 complexed with RNA provides new insights into the CTC family of stress proteins., Fedorov R, Meshcheryakov V, Gongadze G, Fomenkova N, Nevskaya N, Selmer M, Laurberg M, Kristensen O, Al-Karadaghi S, Liljas A, Garber M, Nikonov S, Acta Crystallogr D Biol Crystallogr. 2001 Jul;57(Pt 7):968-76. Epub 2001, Jun 21. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=11418764 11418764]
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__TOC__
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[[Category: Single protein]]
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Thermus thermophilus]]
[[Category: Thermus thermophilus]]
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[[Category: Al-Karadaghi, S.]]
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[[Category: Al-Karadaghi S]]
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[[Category: Fedorov, R.V.]]
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[[Category: Fedorov RV]]
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[[Category: Fomenkova, N.P.]]
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[[Category: Fomenkova NP]]
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[[Category: Garber, M.B.]]
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[[Category: Garber MB]]
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[[Category: Gongadze, G.M.]]
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[[Category: Gongadze GM]]
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[[Category: Kristensen, O.]]
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[[Category: Kristensen O]]
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[[Category: Laurberg, M.]]
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[[Category: Laurberg M]]
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[[Category: Liljas, A.]]
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[[Category: Liljas A]]
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[[Category: Meshcheryakov, V.A.]]
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[[Category: Meshcheryakov VA]]
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[[Category: Nevskaya, N.A.]]
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[[Category: Nevskaya NA]]
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[[Category: Nikonov, S.V.]]
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[[Category: Nikonov SV]]
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[[Category: Selmer, M.]]
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[[Category: Selmer M]]
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[[Category: CD]]
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[[Category: MG]]
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[[Category: 5s rrna-protein complex]]
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[[Category: cadmium ions]]
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[[Category: general stress protein ctc]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Nov 20 14:51:46 2007''
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Current revision

CRYSTAL STRUCTURE OF RIBOSOMAL PROTEIN TL5, ONE OF THE CTC FAMILY PROTEINS, COMPLEXED WITH A FRAGMENT OF 5S RRNA.

PDB ID 1feu

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