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1fkl

From Proteopedia

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[[Image:1fkl.png|left|200px]]
 
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==ATOMIC STRUCTURE OF FKBP12-RAPAYMYCIN, AN IMMUNOPHILIN-IMMUNOSUPPRESSANT COMPLEX==
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The line below this paragraph, containing "STRUCTURE_1fkl", creates the "Structure Box" on the page.
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<StructureSection load='1fkl' size='340' side='right'caption='[[1fkl]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1fkl]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FKL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1FKL FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=RAP:RAPAMYCIN+IMMUNOSUPPRESSANT+DRUG'>RAP</scene></td></tr>
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{{STRUCTURE_1fkl| PDB=1fkl | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1fkl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fkl OCA], [https://pdbe.org/1fkl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1fkl RCSB], [https://www.ebi.ac.uk/pdbsum/1fkl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1fkl ProSAT]</span></td></tr>
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</table>
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===ATOMIC STRUCTURE OF FKBP12-RAPAYMYCIN, AN IMMUNOPHILIN-IMMUNOSUPPRESSANT COMPLEX===
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== Function ==
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[https://www.uniprot.org/uniprot/FKB1A_BOVIN FKB1A_BOVIN] Keeps in an inactive conformation TGFBR1, the TGF-beta type I serine/threonine kinase receptor, preventing TGF-beta receptor activation in absence of ligand. May modulate the RYR1 calcium channel activity. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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(as it appears on PubMed at http://www.pubmed.gov), where 15299838 is the PubMed ID number.
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fk/1fkl_consurf.spt"</scriptWhenChecked>
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{{ABSTRACT_PUBMED_15299838}}
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==About this Structure==
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</jmolCheckbox>
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[[1fkl]] is a 1 chain structure of [[Cyclophilin]] with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FKL OCA].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1fkl ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Cyclophilin]]
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*[[FKBP 3D structures|FKBP 3D structures]]
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__TOC__
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==Reference==
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</StructureSection>
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<ref group="xtra">PMID:15299838</ref><references group="xtra"/>
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[[Category: Bos taurus]]
[[Category: Bos taurus]]
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[[Category: Peptidylprolyl isomerase]]
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[[Category: Large Structures]]
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[[Category: Navia, M A.]]
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[[Category: Navia MA]]
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[[Category: Sintchak, M D.]]
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[[Category: Sintchak MD]]
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[[Category: Thomson, J A.]]
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[[Category: Thomson JA]]
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[[Category: Wilson, K P.]]
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[[Category: Wilson KP]]
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[[Category: Cis-trans prolyl-isomerase]]
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[[Category: Fk506 binding protein]]
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[[Category: Fkbp]]
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[[Category: Fkbp12]]
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[[Category: Rotamase]]
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Current revision

ATOMIC STRUCTURE OF FKBP12-RAPAYMYCIN, AN IMMUNOPHILIN-IMMUNOSUPPRESSANT COMPLEX

PDB ID 1fkl

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