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1fn9

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{{Seed}}
 
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[[Image:1fn9.png|left|200px]]
 
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==CRYSTAL STRUCTURE OF THE REOVIRUS OUTER CAPSID PROTEIN SIGMA 3==
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The line below this paragraph, containing "STRUCTURE_1fn9", creates the "Structure Box" on the page.
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<StructureSection load='1fn9' size='340' side='right'caption='[[1fn9]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1fn9]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Reovirus_sp. Reovirus sp.]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FN9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1FN9 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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{{STRUCTURE_1fn9| PDB=1fn9 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1fn9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fn9 OCA], [https://pdbe.org/1fn9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1fn9 RCSB], [https://www.ebi.ac.uk/pdbsum/1fn9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1fn9 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/SIGM3_REOVD SIGM3_REOVD] Stimulates translation by blocking the activation of the dsRNA-dependent protein kinase EIF2AK2/PKR, thereby inhibiting the host interferon response. Sigma3 prevents the activation of EIF2AK2 by competing with the kinase for dsRNA-binding.<ref>PMID:9268168</ref> The viral outer shell polypeptides, of which sigma-3 is one, impose structural constraints that prevent elongation of nascent transcripts by the RNA-dependent RNA polymerase lambda-3.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fn/1fn9_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1fn9 ConSurf].
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<div style="clear:both"></div>
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===CRYSTAL STRUCTURE OF THE REOVIRUS OUTER CAPSID PROTEIN SIGMA 3===
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==See Also==
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*[[Virus coat proteins 3D structures|Virus coat proteins 3D structures]]
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== References ==
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<references/>
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The line below this paragraph, {{ABSTRACT_PUBMED_11230122}}, adds the Publication Abstract to the page
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 11230122 is the PubMed ID number.
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</StructureSection>
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[[Category: Large Structures]]
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{{ABSTRACT_PUBMED_11230122}}
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[[Category: Reovirus sp]]
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[[Category: Harrison SC]]
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==About this Structure==
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[[Category: Jane-Valbuena J]]
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1FN9 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Reovirus_sp. Reovirus sp.]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FN9 OCA].
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[[Category: Nibert ML]]
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[[Category: Olland AM]]
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==Reference==
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[[Category: Schiff LA]]
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Structure of the reovirus outer capsid and dsRNA-binding protein sigma3 at 1.8 A resolution., Olland AM, Jane-Valbuena J, Schiff LA, Nibert ML, Harrison SC, EMBO J. 2001 Mar 1;20(5):979-89. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11230122 11230122]
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[[Category: Reovirus sp.]]
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[[Category: Single protein]]
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[[Category: Harrison, S C.]]
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[[Category: Jane-Valbuena, J.]]
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[[Category: Nibert, M L.]]
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[[Category: Olland, A M.]]
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[[Category: Schiff, L A.]]
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[[Category: Zinc binding motif]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 03:36:23 2008''
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Current revision

CRYSTAL STRUCTURE OF THE REOVIRUS OUTER CAPSID PROTEIN SIGMA 3

PDB ID 1fn9

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